Afu1g01380 ORF och4 ASPL0000101308 PMID: 20586114|AspGD_REF: ASPL0000111234 classical genetics null och4::PTRa (resistance to pyrithiamine) viable A. fumigatus Afu1g03940 ORF ASPL0000101564 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g03990 ORF thtA ASPL0000101569 PMID: 15338574|AspGD_REF: ASPL0000111263 classical genetics null thtA::hph virulence: normal BALB/c mice immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu1g03990 ORF thtA ASPL0000101569 PMID: 15338574|AspGD_REF: ASPL0000111263 classical genetics null thtA::hph viable A. fumigatus Afu1g03990 ORF thtA ASPL0000101569 PMID: 15338574|AspGD_REF: ASPL0000111263 classical genetics null thtA::hph virulence: normal mouse intravenous infection (immunocompetent BALB/c mice) A. fumigatus Afu1g03990 ORF thtA ASPL0000101569 PMID: 15338574|AspGD_REF: ASPL0000111263 classical genetics null thtA::hph thermotolerance: decreased mutants failed to grow at 48 degrees C but grew well at 42 degrees C A. fumigatus Afu1g04190 ORF ASPL0000101587 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g04260 ORF ENGL1 ASPL0000101593 PMID: 12462524|AspGD_REF: ASPL0000114842 classical genetics null engl1::hph viable A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA viable reduced growth during iron starvation; defect is cured by ferricrocin-supplementation during conidiation A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA chemical compound accumulation: decreased ferricrocin iron-replete conditions decreased hyphal ferricrocin accumulation A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA chemical compound accumulation: increased triacetylfusarinine C increased extracellular triacetylfusarinine C (TAFC) production in mutant detected only during iron starvation but not iron sufficiency; 1.25-fold increased A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA conidial germination: delayed delayed germination during iron-depleted conditions A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA cell size: decreased conidial size is decreased by 13 % A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA resistance to chemicals: decreased hydrogen peroxide high-iron, hydrogen peroxide plates A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA RNA accumulation: decreased sreA mRNA A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA RNA accumulation: increased hapX mRNA A. fumigatus Afu1g04450 ORF sidL ASPL0000101613 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null sidL::ptrA conidiation: decreased mutant displays normal conidiation when supplemented with ferricrocin (which cures ferricrocin-deficiency) A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null abaA::AnpyrG formation of anatomical structure: abnormal conidiophore A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null abaA::AnpyrG conidiation: decreased A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null abaA::AnpyrG viable A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null abaA::AnpyrG autolysis: delayed A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics overexpression abaA::AnpyrG autolysis: increased rate A. fumigatus Afu1g04830 ORF abaA ASPL0000101652 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null abaA::AnpyrG conidial germination: delayed A. fumigatus Afu1g04840 ORF ASPL0000101653 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null viable A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null colony size: decreased ~1.0% the size of WT controls, phenotype not restored by high osmolarity A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null vegetative growth: delayed submerged culture A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null conidiation: increased about a 2-fold increase on plates based on equivalent sized colony sections; increased conidiophore development in submerged culture A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null secondary metabolite production: decreased gliotoxin A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null RNA accumulation: increased gliotoxin brlA mRNA A. fumigatus Afu1g05210 ORF gpgA ASPL0000101690 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null RNA accumulation: delayed gliotoxin gliZ mRNA A. fumigatus Afu1g05240 ORF ASPL0000101693 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null viable A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null cell lysis: increased approximately 34% of hyphal tips were lysed compared to almost none in the wild-type strains A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null thermotolerance: decreased growth of mutant is impaired at temperatures higher than 30 degrees C; phenotype rescued by the addition of sorbitol to the medium A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null alkaline pH resistance: decreased A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null adhesion: decreased decreased adherence to glass slides and cell culture dishes A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null resistance to chemicals: decreased posaconazole A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null resistance to chemicals: decreased voriconazole A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null protein/peptide modification: decreased decreased phosphorylation in the presence of the cell wall stressor Congo Red MpkA A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null protein/peptide modification: increased increased phosphorylation in the presence of the cell wall stresssor Congo Red MpkB-GFP A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20452278|AspGD_REF: ASPL0000111237 classical genetics null virulence: decreased MpkB-GFP other model (mouse retroorbital infection) A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null viable A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null colony size: decreased A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to enzymatic treatment: decreased Glucanex, a compound with high chitinase and glucanase activity; sensitivity overcome by addition of 1 M sorbitol to the medium A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null hyphal growth: abnormal abnormal hyphal structures with elevated branching frequency A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased sodium dodecyl sulfate phenotype reversed by high osmolarity medium A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Congo Red A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Calcofluor White A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null thermotolerance: decreased not able to grow at 48 degrees C ; phenotype reversed by addition of 1 M sorbitol to the medium A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null protein activity: decreased HmgA A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null protein/peptide modification: decreased decreased phosphorylation of MpkA MpkA A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20398212|AspGD_REF: ASPL0000112872 classical genetics null resistance to chemicals: decreased farnesol (100um) growth only partially restored by sorbitol A. fumigatus Afu1g05800 ORF mkk2 ASPL0000101749 PMID: 20398212|AspGD_REF: ASPL0000112872 classical genetics null resistance to chemicals: decreased cytochalasin A A. fumigatus Afu1g05830 ORF ASPL0000101752 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g06700 ORF casA ASPL0000101838 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casA::hph viable A. fumigatus Afu1g06700 ORF casA ASPL0000101838 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casA::hph resistance to chemicals: decreased dithioerythritol A. fumigatus Afu1g06700 ORF casA ASPL0000101838 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casA::hph resistance to chemicals: decreased tunicamycin A. fumigatus Afu1g06700 ORF casA ASPL0000101838 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casA::hph resistance to chemicals: decreased 2-deoxy-D-glucose A. fumigatus Afu1g06700 ORF casA ASPL0000101838 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casA::hph virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null crzA::pyrG viable A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null viable A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased nikkomycin Z (1 microgram/ml) A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased nikkomycin Z (1 microgram/ml) A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased echinochandins (caspofungin, micafungin and anidulafungin) A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null crzA::pyrG RNA accumulation: decreased zfpA mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null RNA accumulation: decreased brlA mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null RNA accumulation: decreased wetA mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null crzA::pyrG viable A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics overexpression alcA::crzA resistance to chemicals: decreased calcium(2+) glycerol plus threonine medium (inducing) 200 and 400 mM calcium chloride A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null crzA::pyrG resistance to chemicals: decreased calcium(2+) 200 and 400 mM calcium chloride A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics repressible alcA::crzA resistance to chemicals: decreased calcium(2+) glucose medium (repressing) 200 and 400 mM calcium chloride A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics overexpression alcA::crzA RNA accumulation: increased pmcB mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics overexpression alcA::crzA RNA accumulation: increased rcnA mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics overexpression alcA::crzA RNA accumulation: increased rfeF mRNA A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG viable A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG metal resistance: decreased calcium(2+) A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG metal resistance: decreased manganese(2+) A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG thermotolerance: decreased A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG conidiation: decreased A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null crzA::pyrG virulence: decreased mouse pulmonary infection A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18456861|AspGD_REF: ASPL0000079988 classical genetics null crzA::pyrG viable A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18456861|AspGD_REF: ASPL0000079988 classical genetics null crzA::pyrG conidial germination: decreased A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18456861|AspGD_REF: ASPL0000079988 classical genetics null crzA::pyrG hyphal growth: decreased A. fumigatus Afu1g06900 ORF crzA ASPL0000101858 PMID: 18456861|AspGD_REF: ASPL0000079988 classical genetics null crzA::pyrG virulence: decreased immunosuppressed mouse pulmonary infection A. fumigatus Afu1g07070 ORF phoB ASPL0000101873 PMID: 18538268|AspGD_REF: ASPL0000111143 classical genetics null viable A. fumigatus Afu1g07070 ORF phoB ASPL0000101873 PMID: 18538268|AspGD_REF: ASPL0000111143 classical genetics null resistance to chemicals: decreased cyclosporin A A. fumigatus Afu1g07070 ORF phoB ASPL0000101873 PMID: 18538268|AspGD_REF: ASPL0000111143 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (low dose model) A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 resistance to chemicals: decreased sodium dodecyl sulfate (50 micrograms/ml) complete medium (repressed condition) A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 resistance to chemicals: decreased Calcofluor White (20 micrograms/ml) complete medium (repressed condition) A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 conidial germination: abnormal complete medium (repressed condition) high frequency of apical branching, random budding and multinucleation; ballooned hyphal tips especially after 15 h of incubation A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 conidiation: decreased complete medium (repressed condition) A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 actin cytoskeleton morphology: abnormal complete medium (repressed condition) actin patches are randomly distributed in mutant strain A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20053626|AspGD_REF: ASPL0000089726 classical genetics null alcA(p)-pmt2 resistance to chemicals: decreased Congo Red (20 micrograms/ml) complete medium (repressed condition) A. fumigatus Afu1g07690 ORF pmt2 ASPL0000101934 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null inviable determined by heterokaryon procedure adapted from A. nidulans protocol A. fumigatus Afu1g09690 ORF ASPL0000102035 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 20038606|AspGD_REF: ASPL0000111094 classical genetics null RNA accumulation: decreased under alkaline zinc-limiting conditions zrfC mRNA A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 20038606|AspGD_REF: ASPL0000111094 classical genetics null RNA accumulation: decreased under alkaline zinc-limiting conditions aspf2 mRNA A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 20038606|AspGD_REF: ASPL0000111094 classical genetics null viable A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 17542914|AspGD_REF: ASPL0000089733 classical genetics null RNA accumulation: decreased zrfA mRNA A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 17542914|AspGD_REF: ASPL0000089733 classical genetics null RNA accumulation: decreased zrfB mRNA A. fumigatus Afu1g10080 ORF zafA ASPL0000102072 PMID: 17542914|AspGD_REF: ASPL0000089733 classical genetics null virulence: decreased 8 wk old out-bred Swiss OF1 male mice zrfB mRNA immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu1g10230 ORF zfpB ASPL0000102087 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased itraconazole A. fumigatus Afu1g10230 ORF zfpB ASPL0000102087 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased caspofungin A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null spore wall formation: abnormal altered conidial surface morphology and hydrophilicity A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null viable A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null oxidative stress resistance: decreased hydrogen peroxide A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null oxidative stress resistance: decreased hypochlorous acid (HOCl) A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null resistance to killing by host cells: decreased purified human neutrophils A. fumigatus Afu1g10380 ORF nrps1 ASPL0000102102 PMID: 16759234|AspGD_REF: ASPL0000111175 classical genetics null virulence: decreased insect infection (Galleria mellonella model system) A. fumigatus Afu1g10740 ORF ASPL0000102137 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB RNA accumulation: delayed brlA mRNA A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB viable A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB colony size: decreased A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB conidiation: delayed A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB conidiation: decreased A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB resistance to chemicals: decreased 6-azauracil A. fumigatus Afu1g11090 ORF clrD ASPL0000102172 PMID: 18849468|AspGD_REF: ASPL0000111114 classical genetics null clrD::AnargB resistance to phagocytosis: normal RAW 264.7 and MH-S cell lines in vitro model of infection A. fumigatus Afu1g11460 ORF bgt1 ASPL0000102209 PMID: 9846753|AspGD_REF: ASPL0000111274 classical genetics null bgt1::hph viable A. fumigatus Afu1g12490 ORF veA ASPL0000102317 PMID: 16002655|AspGD_REF: ASPL0000111262 classical genetics null veA::loxP-phleo/tk conidiation: decreased conidiation reduced on nitrate-containing medium A. fumigatus Afu1g12490 ORF veA ASPL0000102317 PMID: 16002655|AspGD_REF: ASPL0000111262 classical genetics null veA::loxP-phleo/tk viable A. fumigatus Afu1g12600 ORF chsD ASPL0000102328 PMID: 8807804|AspGD_REF: ASPL0000079180 classical genetics null chsD::hph viable A. fumigatus Afu1g12600 ORF chsD ASPL0000102328 PMID: 8807804|AspGD_REF: ASPL0000079180 classical genetics null chsD::hph chemical compound accumulation: decreased chitin 20% reduction in total mycelial chitin content A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null gpaB::pyrG viable A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null gpaB::pyrG colony size: decreased colony size partially restored by exogenous cAMP A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null gpaB::pyrG resistance to killing by host cells: decreased intracellular conidial killing assay with human monocyte derived macrophages A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null gpaB::pyrG protein activity: decreased pksPp-lacZ A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null viable A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null protein activity: decreased pksP-lacZ A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (low-dose model; cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu1g12930 ORF gpaB ASPL0000102361 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null protein activity: decreased cAMP-dependent protein kinase A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16702099|AspGD_REF: ASPL0000078995 classical genetics null sakA::hph viable A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16702099|AspGD_REF: ASPL0000078995 classical genetics null sakA::hph resistance to chemicals: decreased menadione (0.0075 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16702099|AspGD_REF: ASPL0000078995 classical genetics null sakA::hph resistance to chemicals: decreased hydrogen peroxide (2.5 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16702099|AspGD_REF: ASPL0000078995 classical genetics null sakA::hph vegetative growth: decreased A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16834605|AspGD_REF: ASPL0000111501 classical genetics null resistance to chemicals: decreased vanillyl acetone growth of sakA mutant inhibited at concentrations greater than 15 mM A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16834605|AspGD_REF: ASPL0000111501 classical genetics null resistance to chemicals: increased fludioxonil A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 17355596|AspGD_REF: ASPL0000113860 classical genetics null colony shape: abnormal rough surface structure, smaller colonies A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 17355596|AspGD_REF: ASPL0000113860 classical genetics null resistance to chemicals: decreased acetylsalicylic acid (> 5 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 17355596|AspGD_REF: ASPL0000113860 classical genetics null resistance to chemicals: decreased 2,3-dihydroxybenzoate (> 9 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 17355596|AspGD_REF: ASPL0000113860 classical genetics null resistance to chemicals: decreased 2,5-dihydroxybenzoate (> 9 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 21627838|AspGD_REF: ASPL0000166234 classical genetics null resistance to chemicals: decreased benzaldehydes A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null RNA accumulation: absent undetectable by Northern blot dprB mRNA A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null RNA accumulation: absent undetectable by Northern blot dprA mRNA A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 20943191|AspGD_REF: ASPL0000112699 classical genetics null resistance to chemicals: decreased benzoic acid (2.5, 3.0 and 3.5 mM) A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16998074|AspGD_REF: ASPL0000079014 classical genetics null osmotic stress resistance: decreased potassium chloride CM containing 1.4 M KCl growth of mutants inhibited on high-osmolarity medium A. fumigatus Afu1g12940 ORF sakA ASPL0000102362 PMID: 16998074|AspGD_REF: ASPL0000079014 classical genetics null viable A. fumigatus Afu1g13100 ORF ASPL0000102378 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g13140 ORF gpaA ASPL0000102382 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics activation gpaA-(Q204L) conidiation: decreased reduced conidiation on plates and absence of conidiophore formation in liquid-submerged culture A. fumigatus Afu1g13140 ORF gpaA ASPL0000102382 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics dominant negative gpaA-(G203R) colony size: decreased reduced radial growth with normal conidiation levels A. fumigatus Afu1g13200 ORF ASPL0000102388 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g13280 ORF pmi1 ASPL0000102396 PMID: 19574302|AspGD_REF: ASPL0000111101 classical genetics null pmi1::pyrG viable A. fumigatus Afu1g13280 ORF pmi1 ASPL0000102396 PMID: 19574302|AspGD_REF: ASPL0000111101 classical genetics null pmi1::pyrG utilization of carbon source: decreased no growth on CM without mannose supplementation A. fumigatus Afu1g13280 ORF pmi1 ASPL0000102396 PMID: 19574302|AspGD_REF: ASPL0000111101 classical genetics null pmi1::pyrG conidial germination: abnormal mutant conidia cease to grow after two rounds of mitotic division and became enlarged, misshapen and vacuolated, with irregular distribution of chitin in their cell walls A. fumigatus Afu1g13280 ORF pmi1 ASPL0000102396 PMID: 19574302|AspGD_REF: ASPL0000111101 classical genetics null pmi1::pyrG resistance to chemicals: decreased calcium dichloride high levels of mannose are toxic to mutant; also no conidia were produced at 0.5 or 10 mM mannose A. fumigatus Afu1g13280 ORF pmi1 ASPL0000102396 PMID: 19574302|AspGD_REF: ASPL0000111101 classical genetics null pmi1::pyrG chitin deposition: abnormal irregular distribution of chitin in the mutant cell walls A. fumigatus Afu1g13420 ORF ASPL0000102410 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g13740 ORF ASPL0000102442 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g13790 ORF ASPL0000102447 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g13910 ORF ASPL0000102459 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g14100 ORF ASPL0000102478 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g14550 ORF sod3 ASPL0000102522 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null viable A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG conidial germination: abnormal random budding and septation at early stages of germination A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG viable A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG conidiation: decreased mutant produces one third of the conidia produced by wild-type at 37 degrees C and only 3% of wild-type at 50 degrees C A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG formation of anatomical structure: abnormal severe defect in metulae formation observed at 50??C metula A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG virulence: normal severe defect in metulae formation observed at 50??C metula A. fumigatus Afu1g14560 ORF msdS ASPL0000102523 PMID: 18599824|AspGD_REF: ASPL0000111141 classical genetics null msdS::pyrG virulence: normal immunosuppressed mouse pulmonary infection (BALB/c mice (18?20 g)) A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 16151250|AspGD_REF: ASPL0000111338 classical genetics null laeA::pyrG (A. parasiticus pyrG) chemical compound accumulation: decreased gliotoxin A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 16151250|AspGD_REF: ASPL0000111338 classical genetics null conidiation: decreased A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 16151250|AspGD_REF: ASPL0000111338 classical genetics null laeA::pyrG (A. parasiticus pyrG) resistance to phagocytosis: decreased human peripheral blood mononuclear cells A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 16151250|AspGD_REF: ASPL0000111338 classical genetics null laeA::pyrG (A. parasiticus pyrG) virulence: decreased outbred Swiss ICR mice immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 15075281|AspGD_REF: ASPL0000079997 classical genetics null laeA::pyrG viable A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 15075281|AspGD_REF: ASPL0000079997 classical genetics null laeA::pyrG secondary metabolite production: decreased gliotoxin A. fumigatus Afu1g14660 ORF laeA ASPL0000102533 PMID: 19917717|AspGD_REF: ASPL0000111241 classical genetics null resistance to phagocytosis: decreased increased uptake of resting mutant spores is associated with decreased RodAp content A. fumigatus Afu1g14740 ORF ASPL0000102541 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PGL conidial germination: increased rate 37 degrees C, RPMI medium A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PGL viable A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PHL virulence: increased 18 - 20 g female Swiss mice lung invasion was significantly higher in the mutant than in the WT; increased inflammation, necrosis and greater PMN recruitment immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PHL competitive fitness: increased 18 - 20 g female Swiss mice mixed infection with wild-type; mutant fungal burden higher than WT by more than 15-fold immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PHL chemical compound accumulation: increased melanin A. fumigatus Afu1g15440 ORF ags3 ASPL0000102609 PMID: 16531086|AspGD_REF: ASPL0000111182 classical genetics null ags3::PHL resistance to chemicals: increased hydrogen peroxide A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 18333504|AspGD_REF: ASPL0000111427 classical genetics null viable A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 18333504|AspGD_REF: ASPL0000111427 classical genetics null chemical compound accumulation: decreased ergot alkaloid A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 18333504|AspGD_REF: ASPL0000111427 classical genetics null conidiation: absent A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 18333504|AspGD_REF: ASPL0000111427 classical genetics null formation of anatomical structure: abnormal bristle-like conidiophore structures conidiophore A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null chemical compound accumulation: decreased gliotoxin A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 19028996|AspGD_REF: ASPL0000111247 classical genetics null brlA::hygR conidiation: absent no developmental structures produced beyond the stalk stage of differentiation A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 19028996|AspGD_REF: ASPL0000111247 classical genetics null brlA::hygR viable A. fumigatus Afu1g16590 ORF brlA ASPL0000102723 PMID: 19028996|AspGD_REF: ASPL0000111247 classical genetics null brlA::hygR colony color: abnormal white colonies due to the absence of conidia A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG cell lysis: increased A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG viable A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG conidial germination: increased rate mutants germinate about 2 hrs before wild-type A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG protein/peptide accumulation: increased ChiB1 A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG virulence: decreased male BALB/c mice immunosuppressed mouse pulmonary infection (cortisone and cyclophosphamide immunosuppression) A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG resistance to chemicals: decreased Calcofluor White (250 micrograms/ml) A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG resistance to chemicals: decreased Congo Red (250 micrograms/ml) A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG resistance to chemicals: decreased nikkomycin Z (20 micrograms/ml) A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG resistance to chemicals: decreased sodium dodecyl sulfate (60 micrograms/ml) A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG protein/peptide accumulation: decreased Cat1 A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG protein/peptide accumulation: decreased AspHS A. fumigatus Afu1g16950 ORF pig-a ASPL0000102760 PMID: 17501924|AspGD_REF: ASPL0000111498 classical genetics null pig-a::pyrG protein/peptide accumulation: decreased melanin A. fumigatus Afu1g17020 ORF ugd1 ASPL0000102767 PMID: 19709651|AspGD_REF: ASPL0000112187 classical genetics null chemical compound accumulation: decreased glucuronic acid A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null viable A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: increased increased survival in flies insect infection (Toll-deficient flies) A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null chemical compound accumulation: decreased iron A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null virulence: decreased male outbred CD1 mice immunosuppressed mouse pulmonary infection (cyclophosphamide and hydrocortisone acetate immunosuppression) A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to killing by host cells: normal AM harvested from immunocompetent mice About 50% mutants and wild-type killed by alveolar macrophages (AM) by 24h A. fumigatus Afu1g17200 ORF sidC ASPL0000102785 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) resistance to chemicals: decreased fluconazole A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null anaerobic growth: absent A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) resistance to chemicals: decreased voriconazole A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) hyphal growth: abnormal excess hyphal branching A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) virulence: decreased immunosuppressed mouse pulmonary infection (outbred CD1 neutropenic mouse model) A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) viable A. fumigatus Afu2g01260 ORF srbA ASPL0000102957 PMID: 18989462|AspGD_REF: ASPL0000079987 classical genetics null srbA::pyrG (A. paraciticus pyrG) resistance to killing by host cells: normal RAW264.7 macrophage-like cell line A. fumigatus Afu2g01330 ORF ASPL0000102964 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g01570 ORF ASPL0000102987 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g01870 ORF chsA ASPL0000103017 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein/peptide accumulation: normal chitin A. fumigatus Afu2g01870 ORF chsA ASPL0000103017 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein/peptide accumulation: normal beta-1,3-glucan A. fumigatus Afu2g01870 ORF chsA ASPL0000103017 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein activity: decreased chitin synthase A. fumigatus Afu2g01870 ORF chsA ASPL0000103017 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null viable A. fumigatus Afu2g02510 ORF ASPL0000103081 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g02620 ORF akuB ASPL0000103092 PMID: 16400184|AspGD_REF: ASPL0000111161 classical genetics null viable A. fumigatus Afu2g02620 ORF akuB ASPL0000103092 PMID: 16400184|AspGD_REF: ASPL0000111161 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (low-dose model; cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu2g02620 ORF akuB ASPL0000103092 PMID: 20421382|AspGD_REF: ASPL0000112821 classical genetics null virulence: decreased other model (embryonated chick eggs) A. fumigatus Afu2g03310 ORF ASPL0000103160 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g03390 ORF rpdA ASPL0000103168 PMID: 19940017|AspGD_REF: ASPL0000082712 classical genetics null inviable numerous repeated attempts at gene replacement failed A. fumigatus Afu2g03390 ORF rpdA ASPL0000103168 PMID: 19940017|AspGD_REF: ASPL0000082712 classical genetics repressible alcA(p)-rpdA conidiation: decreased A. fumigatus Afu2g03390 ORF rpdA ASPL0000103168 PMID: 19940017|AspGD_REF: ASPL0000082712 classical genetics repressible alcA(p)-rpdA colony size: decreased A. fumigatus Afu2g03640 ORF ASPL0000103191 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g04200 ORF hppD ASPL0000103246 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hppD::ptrA utilization of carbon source: decreased growth of the mutant strain is less dense than the wild-type strain when tyrosine is given as the sole carbon source A. fumigatus Afu2g04200 ORF hppD ASPL0000103246 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hppD::ptrA viable A. fumigatus Afu2g04200 ORF hppD ASPL0000103246 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hppD::ptrA conidiation: decreased A. fumigatus Afu2g04200 ORF hppD ASPL0000103246 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hppD::ptrA chemical compound accumulation: decreased pyomelanin L-tyrosine was given as the sole carbon source A. fumigatus Afu2g04200 ORF hppD ASPL0000103246 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null chemical compound accumulation: decreased pyomelanin no pigment production was observed with the addition of 10 mM l-tyrosine to AMM liquid cultures A. fumigatus Afu2g04220 ORF hmgA ASPL0000103248 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hmgA::ptrA conidiation: decreased A. fumigatus Afu2g04220 ORF hmgA ASPL0000103248 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hmgA::ptrA liquid culture appearance: abnormal no pigment production was observed with the addition of 10 mM L-tyrosine to AMM liquid cultures A. fumigatus Afu2g04220 ORF hmgA ASPL0000103248 PMID: 19028908|AspGD_REF: ASPL0000111248 classical genetics null hmgA::ptrA viable the mycelia of the mutant strains were less dense than wild-type strains A. fumigatus Afu2g05060 ORF aox ASPL0000103331 PMID: 19148712|AspGD_REF: ASPL0000111111 classical genetics repressible chemical compound accumulation: increased reactive oxygen species repression via RNA interference A. fumigatus Afu2g05060 ORF aox ASPL0000103331 PMID: 19148712|AspGD_REF: ASPL0000111111 classical genetics repressible oxidative stress resistance: increased paraquat repression via RNA interference A. fumigatus Afu2g05060 ORF aox ASPL0000103331 PMID: 19148712|AspGD_REF: ASPL0000111111 classical genetics repressible resistance to phagocytosis: decreased repression via RNA interference A. fumigatus Afu2g05150 ORF mp2 ASPL0000103339 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null viable A. fumigatus Afu2g05340 ORF gel4 ASPL0000103358 PMID: 20543062|AspGD_REF: ASPL0000111290 classical genetics null inviable A. fumigatus Afu2g05510 ORF ASPL0000103374 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g05820 ORF ASPL0000103405 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null pmrA::AppyrG (A. parasiticus pyrG) viable A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null pmrA::AppyrG (A. parasiticus pyrG) chitin deposition: abnormal calcofluor stain mislocalized from hyphal tips as displayed by wild-type A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null pmrA::AppyrG (A. parasiticus pyrG) resistance to chemicals: decreased caspofungin (0.5 to 1 microgram/ml) caspofungin treatment caused distorted hyphae in the mutant A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null pmrA::AppyrG (A. parasiticus pyrG) resistance to chemicals: decreased nikkomycin Z drastically swollen hyphae and weakened cell wall architecture A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null pmrA::AppyrG (A. parasiticus pyrG) virulence: normal 6-week-old CD1 male mice immunosuppressed mouse pulmonary infection A. fumigatus Afu2g05860 ORF pmr1 ASPL0000103409 PMID: 20097742|AspGD_REF: ASPL0000111090 classical genetics null resistance to chemicals: increased calcium dichloride (200 mM) A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA viable A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA conidiation: delayed glucose minimal medium A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA utilization of carbon source: decreased fructose|galactose|glucosamine|mannose|sorbose decreased colony sizes A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA viable A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA conidial germination: delayed 10 mM ethanol and 10mM glycerol A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA utilization of carbon source: decreased fructose|galactose|glucosamine|mannose|sorbose A. fumigatus Afu2g05910 ORF hxkA ASPL0000103414 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null hxkA::ptrA protein activity: increased isocitrate lyase A. fumigatus Afu2g06060 ORF ASPL0000103429 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g06150 ORF pdiA ASPL0000103438 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g07570 ORF ASPL0000103479 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null sidA::pyrG virulence: decreased 18 to 22 g male CD1 mice immunosuppressed mouse pulmonary infection A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: decreased completely avirulent in flies A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null chemical compound accumulation: decreased iron A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 17845073|AspGD_REF: ASPL0000111254 classical genetics null virulence: decreased male outbred CD1 mice immunosuppressed mouse pulmonary infection (cyclophosphamide and hydrocortisone acetate immunosuppression) A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to killing by host cells: decreased About 88% mutants and 50% wild-type killed by alveolar macrophages (AM) by 48h A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to phagocytosis: normal alveolar macrophages from immunocompetent mice A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null sidA::pyrG viable A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null sidA::pyrG viable A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null sidA::pyrG conidiation: decreased supplementation with ferricrocin or 1.5 mM iron reverses the conidiation phenotype A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null sidA::pyrG utilization of iron source: decreased A. fumigatus Afu2g07680 ORF sidA ASPL0000103489 PMID: 16113265|AspGD_REF: ASPL0000111188 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (18 to 22 g female BALB/c mice) A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR viable A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR conidial germination: delayed 45 min lag in initiation of germination A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR conidial germination: delayed 45 min lag in initiation of germination A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR colony size: decreased radial growth decreased to about 50% of wild-type A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR hyphal growth: abnormal submerged culture increased apical branching A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 16339716|AspGD_REF: ASPL0000111184 classical genetics null rasB::hygR virulence: decreased CF-1 mice immunosuppressed mouse pulmonary infection (cyclophosphamide and triamcinolone acetonide immunosuppression) A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasB (G16V) colony color: abnormal A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasB (G16V) vegetative growth: increased rate A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) colony size: decreased A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) colony appearance: abnormal decreased peripheral growth zone A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) conidial germination: delayed delay in initiation of germination but then progressed at a wild-type rate once germination began A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) hyphal growth: abnormal irregular apical branching A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) RNA accumulation: increased brlA mRNA A. fumigatus Afu2g07770 ORF rasB ASPL0000103497 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasB (T21N) vegetative growth: decreased A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR viable A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR formation of anatomical structure: abnormal conidiophore stalk completely absent; swollen and abnormally shaped phialides. secondary conidiophores emerging from some vesicles conidiophore A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR conidiation: decreased A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR conidial germination: increased rate A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR cell size: increased mutant conidia were approximately twice the size of normal conidia A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR colony color: abnormal pale in color due to decreased conidia production A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu2g07900 ORF stuA ASPL0000103510 PMID: 16207816|AspGD_REF: ASPL0000111178 classical genetics null stuA::hygR formation of anatomical structure: absent conidiophore stalk A. fumigatus Afu2g08360 ORF pyrG ASPL0000103555 PMID: 8926121|AspGD_REF: ASPL0000111278 classical genetics unspecified pyrG- auxotrophy uridine A. fumigatus Afu2g08360 ORF pyrG ASPL0000103555 PMID: 8926121|AspGD_REF: ASPL0000111278 classical genetics unspecified pyrG- virulence: absent A. fumigatus Afu2g08550 ORF pin1 ASPL0000103574 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g08590 ORF pptA ASPL0000103578 PMID: 21195204|AspGD_REF: ASPL0000165832 classical genetics null pptA::pyrG viable A. fumigatus Afu2g08590 ORF pptA ASPL0000103578 PMID: 21195204|AspGD_REF: ASPL0000165832 classical genetics null pptA::pyrG auxotrophy lysine A. fumigatus Afu2g08590 ORF pptA ASPL0000103578 PMID: 21195204|AspGD_REF: ASPL0000165832 classical genetics null pptA::pyrG colony color: abnormal white colonies A. fumigatus Afu2g08590 ORF pptA ASPL0000103578 PMID: 21195204|AspGD_REF: ASPL0000165832 classical genetics null pptA::pyrG formation of anatomical structure: abnormal loss of green conidial pigment conidium A. fumigatus Afu2g08860 ORF ASPL0000103605 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g09060 ORF ASPL0000103624 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g10300 ORF ASPL0000103745 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g10870 ORF ASPL0000103802 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g11180 ORF flbA ASPL0000103833 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null flbA88 conidiation: delayed delayed conidiation with increased aerial hyphae during early asexual development A. fumigatus Afu2g11180 ORF flbA ASPL0000103833 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null flbA88 conidiation: delayed delayed conidiation with increased aerial hyphae during early asexual development A. fumigatus Afu2g11180 ORF flbA ASPL0000103833 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null flbA::pyrG formation of anatomical structure: decreased flbA88 produces the same phenotype conidiophore A. fumigatus Afu2g11180 ORF flbA ASPL0000103833 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null flbA88 RNA accumulation: delayed brlA mRNA A. fumigatus Afu2g11240 ORF ASPL0000103839 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g11270 ORF ags2 ASPL0000103842 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags2::hph viable A. fumigatus Afu2g11270 ORF ags2 ASPL0000103842 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags2::hph conidiation: decreased malt medium, 25 degrees C A. fumigatus Afu2g11270 ORF ags2 ASPL0000103842 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags2::hph virulence: normal immunosuppressed mouse pulmonary infection (mixed (with wild-type) and single infections tested) A. fumigatus Afu2g11270 ORF ags2 ASPL0000103842 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags2::hph hyphal growth: abnormal dichotomous branching of hyphae A. fumigatus Afu2g11270 ORF ags2 ASPL0000103842 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null competitive fitness: normal immunosuppressed mouse pulmonary infection (wild-type and mutant mixed infection) A. fumigatus Afu2g11320 ORF ASPL0000103847 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g11810 ORF ASPL0000103895 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics null pkaC::phleo viable A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics overexpression conidiation: decreased A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics null chemical compound accumulation: increased pigment A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics overexpression protein activity: increased pksPp-lacZ A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics null colony size: decreased pigment A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC;;hph colony size: decreased small compact colonies A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC;;hph conidiation: decreased A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC;;hph viable A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC;;hph virulence: decreased deletion of both PKA catalytic subunit genes, PkaC and PkaC2, rendered the organism avirulent immunosuppressed mouse pulmonary infection (immunosuppressed with triamcinolone acetonide) A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC;;hph resistance to chemicals: decreased Congo Red A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null viable A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null colony size: decreased A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null vegetative growth: decreased rate A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null conidial germination: decreased rate A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null conidiation: decreased A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null protein activity: decreased pksP-lacZ A. fumigatus Afu2g12200 ORF pkaC ASPL0000103934 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (low-dose model; cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu2g12250 ORF ASPL0000103939 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph utilization of carbon source: decreased acetate|ethanol|proline A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph resistance to killing by host cells: decreased HL-60 differentiated into either macrophage-like or neutrophil-like cells A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph chemical compound accumulation: decreased iron mutant incorporated approximately 50% less iron did than the wild-type and complemented strains A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph virulence: decreased insect infection (Galleria mellonella larva model) A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph virulence: decreased immunosuppressed mouse intravenous infection (neutropenic model - cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu2g12330 ORF acuM ASPL0000103947 PMID: 21062375|AspGD_REF: ASPL0000117840 classical genetics null acuM::hph virulence: decreased immunosuppressed mouse pulmonary infection (high-dose cortisone acetate immunosuppression) A. fumigatus Afu2g12370 ORF ASPL0000103951 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG viable A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG colony size: decreased phenotype prominant at high temperature (48 degrees C) A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG conidial germination: delayed A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG resistance to chemicals: decreased hydrogen peroxide 17% larger inhibition zone than wild-type A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG resistance to chemicals: decreased diamide|menadione A. fumigatus Afu2g12640 ORF gprD ASPL0000103978 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprD::pyrG virulence: decreased female BALB/c mice immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression; low-dose model) A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null viable A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics overexpression protein activity: increased ethanol medium (inducing condition) calcineurin A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null RNA accumulation: increased rfeF mRNA A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null resistance to chemicals: increased hydrogen peroxide (2.5 mM) A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 20078882|AspGD_REF: ASPL0000089732 classical genetics null resistance to chemicals: increased menadione (30 micromolar) A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics null cbpA::AppyrG (A. parasiticus pyrG) resistance to chemicals: increased calcium dichloride (200 mM) the calcineurin inhibitor FK506 reverses the increased calcium resistance phenotype A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics null cbpA::AppyrG (A. parasiticus pyrG) viable A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics overexpression RNA accumulation: decreased decreased the expression in response to CaCl2 chsA mRNA A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics overexpression RNA accumulation: decreased decreased the expression in response to CaCl2 calA mRNA A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics null cbpA::AppyrG (A. parasiticus pyrG) colony size: decreased A. fumigatus Afu2g13060 ORF cbpA ASPL0000104020 PMID: 19252123|AspGD_REF: ASPL0000079986 classical genetics overexpression RNA accumulation: decreased decreased the expression in response to CaCl2 vcxA mRNA A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR cell size: increased slightly larger conidia and conidiophores A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR conidial germination: increased rate A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR colony color: abnormal delay in brown pigmentation A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR viable A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR conidiation: decreased A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR adhesion: decreased fibronectin coated wells A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR virulence: decreased insect infection (Galleria mellonella larvae) A. fumigatus Afu2g13260 ORF medA ASPL0000104040 PMID: 19889083|AspGD_REF: ASPL0000082448 classical genetics null medA::hygR virulence: decreased immunosuppressed mouse pulmonary infection A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 12553940|AspGD_REF: ASPL0000111267 classical genetics null colony size: decreased A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 12553940|AspGD_REF: ASPL0000111267 classical genetics null viable A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 9126623|AspGD_REF: ASPL0000082459 classical genetics null chsE::hph conidiation: decreased partially restored by growth in osmotic stabilizer A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 9126623|AspGD_REF: ASPL0000082459 classical genetics null chsE::hph viable A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 9126623|AspGD_REF: ASPL0000082459 classical genetics null chsE::hph virulence: normal immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu2g13440 ORF chsE ASPL0000104059 PMID: 9126623|AspGD_REF: ASPL0000082459 classical genetics null chsE::hph hyphal growth: abnormal balloon-shaped swellings along their length and occasionally at hyphal tips, swollen vesicles and phialides, collapsed stipes, normal septa A. fumigatus Afu2g13450 ORF ASPL0000104060 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g14030 ORF ASPL0000104118 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g14040 ORF ASPL0000104119 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g14360 ORF eng2 ASPL0000104151 PMID: 20619350|AspGD_REF: ASPL0000165818 classical genetics null eng2::hph viable A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null viable A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null RNA accumulation: absent brlA mRNA A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null RNA accumulation: delayed abaA mRNA A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null RNA accumulation: absent gliZ mRNA A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null vegetative growth: increased A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null viability: decreased at days 4 and 5 A. fumigatus Afu2g14680 ORF flbB ASPL0000104182 PMID: 20852021|AspGD_REF: ASPL0000111597 classical genetics null conidiation: decreased even after 96 h in submerged liquid culture. wild-type produced conidiophores within 18 hrs A. fumigatus Afu2g16040 ORF ASPL0000104321 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g16600 ORF ASPL0000104379 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g16710 ORF ASPL0000104390 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal brown color conidium A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 16988817|AspGD_REF: ASPL0000111132 classical genetics null abr2::hph viable A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 16988817|AspGD_REF: ASPL0000111132 classical genetics null abr2::hph colony color: abnormal brown conidia A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 16988817|AspGD_REF: ASPL0000111132 classical genetics null abr2::hph virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 16988817|AspGD_REF: ASPL0000111132 classical genetics null abr2::hph formation of anatomical structure: abnormal brown conidia with less surface ornamentation conidium A. fumigatus Afu2g17530 ORF abr2 ASPL0000104470 PMID: 19156203|AspGD_REF: ASPL0000113140 classical genetics null virulence: increased insect infection (Galleria mellonella) A. fumigatus Afu2g17540 ORF abr1 ASPL0000104471 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal brown color conidium A. fumigatus Afu2g17540 ORF abr1 ASPL0000104471 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 11350964|AspGD_REF: ASPL0000111442 classical genetics null colony color: abnormal yellowish-green colonies due to altered conidial pigment A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 11350964|AspGD_REF: ASPL0000111442 classical genetics null chemical compound accumulation: decreased 1,3,6,8-tetrahydroxynaphthalene A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 11350964|AspGD_REF: ASPL0000111442 classical genetics null chemical compound accumulation: decreased flaviolin A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 21501368|AspGD_REF: ASPL0000166037 classical genetics null ayg1::hph induction of host response: decreased mutants fails to exert an inhibitory effect on STS-induced caspase-3 processing and host cell apoptosis A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal yellow color, turns green at later stages of growth conidium A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17550 ORF ayg1 ASPL0000104472 PMID: 19156203|AspGD_REF: ASPL0000113140 classical genetics null virulence: increased insect infection (Galleria mellonella) A. fumigatus Afu2g17560 ORF arp2 ASPL0000104473 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal reddish pink color conidium A. fumigatus Afu2g17560 ORF arp2 ASPL0000104473 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17560 ORF arp2 ASPL0000104473 PMID: 19156203|AspGD_REF: ASPL0000113140 classical genetics null virulence: increased insect infection (Galleria mellonella) A. fumigatus Afu2g17580 ORF arp1 ASPL0000104475 PMID: 9383199|AspGD_REF: ASPL0000111363 classical genetics null arp1::hph viable A. fumigatus Afu2g17580 ORF arp1 ASPL0000104475 PMID: 9383199|AspGD_REF: ASPL0000111363 classical genetics null arp1::hph colony color: abnormal reddish-pink colonies A. fumigatus Afu2g17580 ORF arp1 ASPL0000104475 PMID: 9383199|AspGD_REF: ASPL0000111363 classical genetics null interaction with host/environment: increased increased C3 complement binding to mutant cells A. fumigatus Afu2g17580 ORF arp1 ASPL0000104475 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal reddish pink color conidium A. fumigatus Afu2g17580 ORF arp1 ASPL0000104475 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 12464010|AspGD_REF: ASPL0000111268 classical genetics null resistance to killing by host cells: decreased human monocyte-derived macrophages A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 9620950|AspGD_REF: ASPL0000079252 classical genetics null resistance to phagocytosis: decreased A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 9620950|AspGD_REF: ASPL0000079252 classical genetics null virulence: decreased mouse pulmonary infection (7 wk-old BALB/c mice) A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 11350964|AspGD_REF: ASPL0000111442 classical genetics null colony color: abnormal white colonies due to lack of conidial pigment A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 15321679|AspGD_REF: ASPL0000111344 classical genetics reduction of function pksP-(alb1-RNAi) colony color: abnormal white colonies due to lack of conidial pigment, intermediate phenotypes also seen with RNAi A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 16953804|AspGD_REF: ASPL0000111434 classical genetics null resistance to phagocytosis: decreased A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 21747802|AspGD_REF: ASPL0000166432 classical genetics null induction of host response: abnormal mutant conidia are found in acidified phagolysosomes wheras wild-type conidia are found in phagolysosomes of neutral pH A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 21501368|AspGD_REF: ASPL0000166037 classical genetics null induction of host response: decreased mutants fails to exert an inhibitory effect on STS-induced caspase-3 processing; decreased IkB activation A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null formation of anatomical structure: abnormal white color conidium A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 10515939|AspGD_REF: ASPL0000081735 classical genetics null viable A. fumigatus Afu2g17600 ORF pksP ASPL0000104477 PMID: 19156203|AspGD_REF: ASPL0000113140 classical genetics null virulence: increased insect infection (Galleria mellonella) A. fumigatus Afu2g18030 ORF fgaCat ASPL0000104522 PMID: 21409592|AspGD_REF: ASPL0000165834 classical genetics null viable A. fumigatus Afu2g18030 ORF fgaCat ASPL0000104522 PMID: 21409592|AspGD_REF: ASPL0000165834 classical genetics null secondary metabolite production: decreased chanoclavine-I A. fumigatus Afu2g18040 ORF dmaW ASPL0000104523 PMID: 15933009|AspGD_REF: ASPL0000111438 classical genetics null secondary metabolite production: decreased ergot alkaloid A. fumigatus Afu2g18040 ORF dmaW ASPL0000104523 PMID: 15933009|AspGD_REF: ASPL0000111438 classical genetics null viable A. fumigatus Afu2g18050 ORF fgaOx1 ASPL0000104524 PMID: 21409592|AspGD_REF: ASPL0000165834 classical genetics null viable A. fumigatus Afu2g18050 ORF fgaOx1 ASPL0000104524 PMID: 21409592|AspGD_REF: ASPL0000165834 classical genetics null secondary metabolite production: decreased chanoclavine-I A. fumigatus Afu3g00590 ORF aspHS ASPL0000104578 PMID: 21658997|AspGD_REF: ASPL0000166260 classical genetics null viable A. fumigatus Afu3g00590 ORF aspHS ASPL0000104578 PMID: 21658997|AspGD_REF: ASPL0000166260 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags1::hph viable A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags1::hph conidiation: decreased malt medium, 25 degrees C A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags1::hph virulence: normal mixed (with wild-type) and single infections tested immunosuppressed mouse pulmonary infection A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags1::hph resistance to chemicals: decreased nikkomycin Z A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null ags1::hph resistance to chemicals: decreased Congo Red A. fumigatus Afu3g00910 ORF ags1 ASPL0000104611 PMID: 15746357|AspGD_REF: ASPL0000111205 classical genetics null competitive fitness: normal immunosuppressed mouse pulmonary infection (wild-type and mutant mixed infection) A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 9353056|AspGD_REF: ASPL0000111276 classical genetics null cat1::hph viable A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 9353056|AspGD_REF: ASPL0000111276 classical genetics null cat1::hph resistance to killing by host cells: normal human polymorphonuclear leukocytes A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 9353056|AspGD_REF: ASPL0000111276 classical genetics null cat1::hph virulence: normal Swiss mice immunosuppressed mouse pulmonary infection (cortisone immunosuppression) A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 9150225|AspGD_REF: ASPL0000079213 classical genetics null viable A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 9150225|AspGD_REF: ASPL0000079213 classical genetics null resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu3g02270 ORF cat1 ASPL0000104749 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu3g02970 ORF gprA ASPL0000104818 PMID: 21349972|AspGD_REF: ASPL0000165814 classical genetics null viable A. fumigatus Afu3g03400 ORF sidF ASPL0000104859 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: increased increased survival in flies insect infection (Toll-deficient flies) A. fumigatus Afu3g03400 ORF sidF ASPL0000104859 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null viable A. fumigatus Afu3g03400 ORF sidF ASPL0000104859 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to phagocytosis: normal alveolar macrophages from immunocompetent mice A. fumigatus Afu3g03400 ORF sidF ASPL0000104859 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to killing by host cells: decreased alveolar macrophages from immunocompetent mice About 75% mutants and 50% wild-type killed by alveolar macrophages (AM) by 48h A. fumigatus Afu3g03400 ORF sidF ASPL0000104859 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu3g03420 ORF sidD ASPL0000104861 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null viable A. fumigatus Afu3g03420 ORF sidD ASPL0000104861 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: decreased insect infection (Toll-deficient flies) A. fumigatus Afu3g03420 ORF sidD ASPL0000104861 PMID: 20659583|AspGD_REF: ASPL0000112779 classical genetics null resistance to killing by host cells: normal AM harvested from immunocompetent mice About 50% mutants and wild-type killed by alveolar macrophages (AM) by 24 h A. fumigatus Afu3g03420 ORF sidD ASPL0000104861 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu3g03650 ORF sidG ASPL0000104884 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null viable A. fumigatus Afu3g03650 ORF sidG ASPL0000104884 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: increased increased survival in flies insect infection (Toll-deficient flies) A. fumigatus Afu3g03650 ORF sidG ASPL0000104884 PMID: 17845073|AspGD_REF: ASPL0000111254 phenotype assays null virulence: normal male outbred CD1 mice immunosuppressed mouse pulmonary infection (cyclophosphamide and hydrocortisone acetate immunosuppression) A. fumigatus Afu3g03660 ORF estB ASPL0000104885 PMID: 17586718|AspGD_REF: ASPL0000111122 classical genetics null estB::hph viable A. fumigatus Afu3g03660 ORF estB ASPL0000104885 PMID: 17586718|AspGD_REF: ASPL0000111122 classical genetics null estB::hph utilization of iron source: decreased slower growth rate when triacetylfusarinine C is the only iron source A. fumigatus Afu3g03660 ORF estB ASPL0000104885 PMID: 17586718|AspGD_REF: ASPL0000111122 classical genetics null estB::hph protein activity: decreased triacetylfusarinine C esterase A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null RNA accumulation: decreased presence of DTT tigA mRNA A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null RNA accumulation: decreased presence of DTT bipA mRNA A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null RNA accumulation: decreased presence of DTT bipA mRNA A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null RNA accumulation: decreased presence of DTT pdiA mRNA A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null resistance to chemicals: decreased caspofungin A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null conidiation: decreased conidiation decreased on solid medium A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null resistance to chemicals: decreased paraquat A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null resistance to chemicals: decreased Calcofluor White growth restored by osmotic stabilization with sorbitol; apical lysis was observed A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null thermotolerance: decreased less than 1% of the plated conidia survived 24 h at 45 degrees C whereas about 5% of wild-type survive A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (single dose triamcinolone acetonide transient immunosuppression) A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 19132084|AspGD_REF: ASPL0000111489 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null hacA::hph conidiation: decreased A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null hacA::hph viable A. fumigatus Afu3g04070 ORF hacA ASPL0000104926 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null hacA::hph virulence: decreased extent of fungal growth and tissue damage was relatively lower in the hacA mutant-infected lungs immunosuppressed mouse pulmonary infection (triamcinolone acetonide immunosuppression; intranasal infection with conidia) A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG conidiation: decreased partially rescued by growth at temperatures at or below 30 degrees C; fully rescued by osmotic stabilizers (1.2 M sorbitol or 1% glycerol) A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG virulence: decreased CD1 mice immunosuppressed mouse pulmonary infection (immunosuppressed with cyclophosphamide or triamcinolone acetonide) A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG protein activity: decreased hexokinase A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG viability: decreased strains grown on SMM after incubation at 37 degrees C decrease in survival of conidia compared to wild-type control strains A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG heat sensitivity: decreased temperature sensitive phenotype observed at temperatures above 42 degrees C A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG formation of anatomical structure: abnormal a wide range of conidial morphologies is produced in orlA mutants conidium A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG hyphal growth: abnormal GMM at 37 degrees C dysmorphic hyphae with shorter length compartments between septa, truncated hyphal tips with knobby, abnormal branching - high GMM (>4% glucose) or osmotic stabilizing media partially rescued the hyphal defects A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG resistance to chemicals: decreased Calcofluor White|Congo Red|nikkomycin Z A. fumigatus Afu3g05650 ORF orlA ASPL0000104981 PMID: 20545865|AspGD_REF: ASPL0000111235 classical genetics null orlA::AppyrG viable A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta viable A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta sterile incubated under established conditions for 6 months mating assays with MAT1-1 strains A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta RNA accumulation: increased increased on minimal medium although strain-specific differences were observed ppgA mRNA A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta hyphal growth: abnormal reduced hyphal extension A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta colony color: abnormal darkening of the colony's reverse side was observed A. fumigatus Afu3g06170 ORF MAT1-2 ASPL0000105028 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null mat1-2-delta formation of anatomical structure: absent cleistothecium A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) viable A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) colony size: decreased 96 h growth at 37 degrees C mutants form more compact colony with reduced aerial hyphae compared to control strains A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) colony color: abnormal white colony color due to loss of conidia production A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) conidiation: decreased A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) hyphal growth: abnormal frequent branching and blunted, curly tips at the hyphal termini A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) chemical compound accumulation: decreased superoxide less superoxide in hyphal tips but more at positions where multiple polarity axes were initiated A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) fermentative growth: increased superoxide increased ethanol production in liquid culture A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) virulence: increased increased virulence but decreased fungal burden in insects insect infection (Galleria mellonella larvae) A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) virulence: normal outbred CD-1 female mice no significant difference in survival between wild-type and mutant immunosuppressed mouse pulmonary infection (steroid model, triamcinolone immunosuppression) A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) virulence: normal no significant difference in survival between wild-type and mutant immunosuppressed mouse pulmonary infection (neutropenic model, cyclophosphamide and triamcinolone immunosuppression) A. fumigatus Afu3g06300 ORF racA ASPL0000105041 PMID: 21183690|AspGD_REF: ASPL0000164317 classical genetics null racA::pyrG (A. parasiticus pyrG) formation of anatomical structure: abnormal swollen and misshapen phialides, branched stalks, and fewer phialides and conidia; defect largely rescued by SAB medium conidiophore A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null viable A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null heat sensitivity: increased elevated temperature (42 deg C) sensitivity is remediated by 1M sucrose A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null resistance to chemicals: decreased Calcofluor White (30 ug/ml) permissive temperature (37 deg C) sensitivity is remediated by 1M sucrose A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null resistance to chemicals: decreased hygromycin B (25 ug/ml) permissive temperature (37 deg C) A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null conidiation: absent elevated temperature (50 deg C) A. fumigatus Afu3g06450 ORF pmt1 ASPL0000105056 PMID: 17905922|AspGD_REF: ASPL0000111223 classical genetics null conidial germination: delayed elevated temperature (42 deg C) germination is normal at 37 deg C A. fumigatus Afu3g06490 ORF ASPL0000105060 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g06530 ORF sC ASPL0000105064 PMID: 11479709|AspGD_REF: ASPL0000081688 classical genetics unspecified resistance to chemicals: increased selenate A. fumigatus Afu3g07020 ORF anxc4 ASPL0000105114 PMID: 21640208|AspGD_REF: ASPL0000166258 classical genetics null RNA accumulation: decreased Afu5g06240 mRNA A. fumigatus Afu3g07020 ORF anxc4 ASPL0000105114 PMID: 21640208|AspGD_REF: ASPL0000166258 classical genetics null RNA accumulation: increased Afu1g16840 mRNA TCTP mRNA A. fumigatus Afu3g07020 ORF anxc4 ASPL0000105114 PMID: 21640208|AspGD_REF: ASPL0000166258 classical genetics null protein/peptide accumulation: decreased Sdh1 A. fumigatus Afu3g07020 ORF anxc4 ASPL0000105114 PMID: 21640208|AspGD_REF: ASPL0000166258 classical genetics null viable A. fumigatus Afu3g07020 ORF anxc4 ASPL0000105114 PMID: 21640208|AspGD_REF: ASPL0000166258 classical genetics null RNA accumulation: increased Afu5g09230 mRNA transaldolase mRNA A. fumigatus Afu3g07140 ORF fluG ASPL0000105125 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null fluG::pyrG RNA accumulation: delayed brlA mRNA A. fumigatus Afu3g07140 ORF fluG ASPL0000105125 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null fluG::pyrG conidiation: delayed delayed conidiation with increased aerial hyphae during early asexual development A. fumigatus Afu3g07140 ORF fluG ASPL0000105125 PMID: 17030990|AspGD_REF: ASPL0000081395 classical genetics null fluG::pyrG viable A. fumigatus Afu3g07170 ORF ASPL0000105128 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g08080 ORF ASPL0000105211 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g08200 ORF ams1 ASPL0000105223 PMID: 19240271|AspGD_REF: ASPL0000079951 classical genetics null conidiation: decreased especially at a higher temperature (37 and 50 degrees C) A. fumigatus Afu3g08200 ORF ams1 ASPL0000105223 PMID: 19240271|AspGD_REF: ASPL0000079951 classical genetics null viable A. fumigatus Afu3g08200 ORF ams1 ASPL0000105223 PMID: 19240271|AspGD_REF: ASPL0000079951 classical genetics null conidial germination: abnormal random budding and septation at an early stages of germination A. fumigatus Afu3g08200 ORF ams1 ASPL0000105223 PMID: 19240271|AspGD_REF: ASPL0000079951 classical genetics null septum formation: abnormal random septation at an early stages of germination A. fumigatus Afu3g08200 ORF ams1 ASPL0000105223 PMID: 19240271|AspGD_REF: ASPL0000079951 classical genetics null hyphal growth: abnormal swollen hyphae A. fumigatus Afu3g08470 ORF ASPL0000105250 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g08840 ORF ASPL0000105285 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null adhesion: decreased extracellular matrix derived from A549 human alveolar epithelial cells dormant conidia A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null cspA::phl and cspA::hygR viable A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null cspA::phl and cspA::hygR viable A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null adhesion: decreased extracellular matrix (ECM) derived from A549 lung cells A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null resistance to phagocytosis: decreased human monocyte-derived macrophages A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null resistance to killing by host cells: decreased human monocyte-derived macrophages A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null resistance to enzymatic treatment: decreased A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics overexpression conidial germination: decreased A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics overexpression resistance to enzymatic treatment: increased A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics overexpression colony size: decreased A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null virulence: normal 6 week old female ICR mice immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null conidial germination: increased rate A. fumigatus Afu3g08990 ORF cspA ASPL0000105300 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null virulence: normal Six-week-old female ICR mice immunosuppressed mouse pulmonary infection (cyclophosphamide immunosuppression) A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR resistance to chemicals: increased nikkomycin Z A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR viable A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR virulence: increased insect infection (G. melonella larvae) A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR virulence: increased immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppressed) A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR adhesion: normal A. fumigatus Afu3g09820 ORF dvrA ASPL0000105380 PMID: 20675576|AspGD_REF: ASPL0000111231 classical genetics null dvrA::hygR virulence: normal immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression, (non neutropenic mice) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR colony size: decreased A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR viable A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics null pkaR::HygR viable A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR conidial germination: delayed A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR conidiation: decreased A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR hyphal growth: abnormal short, wide hyphae with thickened cell walls A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR oxidative stress resistance: decreased hydrogen peroxide (0.005-0.05%) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR oxidative stress resistance: decreased diamide (3-10 mg/ml) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR oxidative stress resistance: decreased menadione (25-100 mg/ml) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR oxidative stress resistance: decreased paraquat (22.5-45 mg/ml) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR virulence: decreased 20-24g CF-1 female mice immunosuppressed mouse pulmonary infection (cyclophosphamide and triamcinolone acetonide immunosuppression) A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR colony color: abnormal A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 16861675|AspGD_REF: ASPL0000079008 classical genetics null pkaR::HygR formation of anatomical structure: abnormal conidiophore A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 19124579|AspGD_REF: ASPL0000111112 classical genetics null viability: decreased upon storage in water, mutant conidia retained 18% viability compared to 100% for wild-type A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 19124579|AspGD_REF: ASPL0000111112 classical genetics null cell size: increased mutant conidia have a larger mean diameter than wild-type conidia and are also more variable in size; the size heterogeneity increases over the course of overnight storage in distilled water A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 19124579|AspGD_REF: ASPL0000111112 classical genetics null conidial germination: premature initiation of conidial germination A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 19124579|AspGD_REF: ASPL0000111112 classical genetics null resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 19124579|AspGD_REF: ASPL0000111112 classical genetics null hyphal growth: abnormal mutant has increased in hyphal diameter and irregularly spaced septa; each hyphal segment contained considerably more nuclei than wild-type A. fumigatus Afu3g10000 ORF pkaR ASPL0000105398 PMID: 18539819|AspGD_REF: ASPL0000111142 classical genetics null protein activity: increased pksPp-lacZ A. fumigatus Afu3g10070 ORF ASPL0000105404 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g10450 ORF ASPL0000105443 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null viable A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null colony size: decreased A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to enzymatic treatment: decreased Glucanex, a compound with high chitinase and glucanase activity; sensitivity overcome by addition of 1 M sorbitol to the medium A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null hyphal growth: abnormal abnormal hyphal structures with elevated branching frequency A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased sodium dodecyl sulfate phenotype reversed by high osmolarity medium A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Congo Red A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Calcofluor White A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null thermotolerance: decreased not able to grow at 48 degrees C ; phenotype reversed by addition of 1 M sorbitol to the medium A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null protein activity: decreased HmgA A. fumigatus Afu3g11080 ORF bck1 ASPL0000105506 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null protein/peptide modification: decreased decreased phosphorylation of MpkA MpkA A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR viable A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR chemical compound excretion: increased soluble orange pigment A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR conidiation: decreased A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR conidiation: decreased cell surface of mutant conidia were relatively smooth as observed by scanning electron micrograph A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR conidial germination: increased rate Sabouraud broth approximately 2 hrs earlier than wild-type strains A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR resistance to chemicals: increased hydrogen peroxide germlings , but not conidia, were significantly more resistant to hydrogen peroxide A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR RNA accumulation: decreased ecm33 mRNA A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null ace2::hygR formation of anatomical structure: abnormal many conidiophores of the ace2 mutant lacked phialides, some had phialides that were irregularly shaped or branched conidiophore A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null induction of host response: increased mutant induced a higher pro-inflammatory response (IL-6, MCP-1, TNF, MPO) in mice immunosuppressed mouse pulmonary infection A. fumigatus Afu3g11250 ORF ace2 ASPL0000105523 PMID: 19220748|AspGD_REF: ASPL0000111110 classical genetics null virulence: increased immunosuppressed mouse pulmonary infection A. fumigatus Afu3g11330 ORF atfA ASPL0000105531 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null viable dprA mRNA A. fumigatus Afu3g11330 ORF atfA ASPL0000105531 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null RNA accumulation: absent dprA mRNA A. fumigatus Afu3g11710 ORF ASPL0000105567 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g11970 ORF pacC ASPL0000105593 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics gain of function PacCc (gain of function, alkalinity-mimicking mutation) RNA accumulation: increased dprB mRNA A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 16040966|AspGD_REF: ASPL0000078953 classical genetics null chemical compound accumulation: decreased prostoglandin A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) viable A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) conidiation: decreased A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) cell shape: abnormal conidia displayed an oval shape and were significantly larger than those of wild-type A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) conidial germination: abnormal conidia germinate faster than wild-type in shaking cultures and slower in stationary cultures A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) resistance to chemicals: increased hydrogen peroxide at both room temperature and 37 degrees C A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) resistance to phagocytosis: decreased primary murine alveolar macrophages A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) resistance to killing by host cells: decreased primary murine alveolar macrophages three times as many mutant conidia were killed compared to wild-type conidia A. fumigatus Afu3g12120 ORF ppoC ASPL0000105608 PMID: 18443090|AspGD_REF: ASPL0000111253 classical genetics null ppoC::argB (A. nidulans argB) virulence: normal immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression or cortisone acetate only immunosupression) A. fumigatus Afu3g12290 ORF dim1 ASPL0000105625 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g12300 ORF ASPL0000105626 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu3g12690 ORF glfA ASPL0000105665 PMID: 19563461|AspGD_REF: ASPL0000111104 classical genetics null ugm1::HPH adhesion: increased increased adhesion to glass after 4, 6 and 10 h of germination in Sabouraud liquid medium A. fumigatus Afu3g12690 ORF glfA ASPL0000105665 PMID: 19563461|AspGD_REF: ASPL0000111104 classical genetics null ugm1::HPH viable A. fumigatus Afu3g12690 ORF glfA ASPL0000105665 PMID: 19563461|AspGD_REF: ASPL0000111104 classical genetics null ugm1::HPH colony size: decreased 48 hrs growth at 30, 45 and 50 degrees C A. fumigatus Afu3g12690 ORF glfA ASPL0000105665 PMID: 19563461|AspGD_REF: ASPL0000111104 classical genetics null ugm1::HPH virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu3g12690 ORF glfA ASPL0000105665 PMID: 19563461|AspGD_REF: ASPL0000111104 classical genetics null ugm1::HPH hyphal growth: abnormal increased hyphal branching and hyphal diameter immunosuppressed mouse pulmonary infection A. fumigatus Afu3g12700 ORF glfB ASPL0000105666 PMID: 19840949|AspGD_REF: ASPL0000111098 classical genetics null viable A. fumigatus Afu3g12700 ORF glfB ASPL0000105666 PMID: 19840949|AspGD_REF: ASPL0000111098 classical genetics null thermotolerance: decreased colonies slightly smaller at 42 and 47 degrees than at 37 degrees C A. fumigatus Afu3g12700 ORF glfB ASPL0000105666 PMID: 19840949|AspGD_REF: ASPL0000111098 classical genetics null vegetative growth: decreased rate colonies slightly smaller at 42 and 47 degrees than at 37 degrees C A. fumigatus Afu3g12700 ORF glfB ASPL0000105666 PMID: 19840949|AspGD_REF: ASPL0000111098 classical genetics null colony size: decreased colonies slightly smaller than wild-type at 28, 37, 42 and 47 degrees C A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 18757566|AspGD_REF: ASPL0000081077 classical genetics overexpression formation of anatomical structure: increased cleistothecium A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null viable A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null resistance to chemicals: decreased Calcofluor White A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null resistance to chemicals: decreased Congo Red hyphal tip swelling A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null hyphal growth: abnormal hyphae of the mutant appeared stunted, sometimes with swollen hyphal tips that occasionally burst A. fumigatus Afu3g13870 ORF nsdD ASPL0000105780 PMID: 20348388|AspGD_REF: ASPL0000111085 classical genetics null resistance to chemicals: increased nikkomycin Z A. fumigatus Afu3g14140 ORF casB ASPL0000105805 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casB::ble resistance to chemicals: decreased 2-deoxy-D-glucose A. fumigatus Afu3g14140 ORF casB ASPL0000105805 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casB::ble viable A. fumigatus Afu3g14140 ORF casB ASPL0000105805 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casB::ble resistance to chemicals: decreased dithioerythritol A. fumigatus Afu3g14140 ORF casB ASPL0000105805 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casB::ble resistance to chemicals: decreased tunicamycin A. fumigatus Afu3g14140 ORF casB ASPL0000105805 PMID: 17176258|AspGD_REF: ASPL0000079020 classical genetics null casB::ble virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu3g14420 ORF chsG ASPL0000105832 PMID: 8736545|AspGD_REF: ASPL0000111281 classical genetics null hyphal growth: abnormal decreased hyphal length A. fumigatus Afu3g14420 ORF chsG ASPL0000105832 PMID: 8736545|AspGD_REF: ASPL0000111281 classical genetics null colony size: decreased A. fumigatus Afu3g14420 ORF chsG ASPL0000105832 PMID: 8736545|AspGD_REF: ASPL0000111281 classical genetics null conidiation: decreased A. fumigatus Afu3g14420 ORF chsG ASPL0000105832 PMID: 12553940|AspGD_REF: ASPL0000111267 classical genetics null colony size: decreased A. fumigatus Afu3g14420 ORF chsG ASPL0000105832 PMID: 12553940|AspGD_REF: ASPL0000111267 classical genetics null viable A. fumigatus Afu4g00860 ORF dprA ASPL0000106005 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null viable A. fumigatus Afu4g00860 ORF dprA ASPL0000106005 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null conidial germination: decreased when 2 mM H2O2 is added to the medium, germination is impaired A. fumigatus Afu4g00860 ORF dprA ASPL0000106005 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null protein activity: decreased CatA A. fumigatus Afu4g03610 ORF phoD ASPL0000106180 PMID: 18538268|AspGD_REF: ASPL0000111143 classical genetics null viable A. fumigatus Afu4g03610 ORF phoD ASPL0000106180 PMID: 18538268|AspGD_REF: ASPL0000111143 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (low dose model) A. fumigatus Afu4g04040 ORF pptB ASPL0000106223 PMID: 21195204|AspGD_REF: ASPL0000165832 classical genetics null pptB::pyrG inviable A. fumigatus Afu4g04180 ORF chsB ASPL0000106236 PMID: 8953267|AspGD_REF: ASPL0000080116 classical genetics null chsB::argB viable A. fumigatus Afu4g04180 ORF chsB ASPL0000106236 PMID: 8953267|AspGD_REF: ASPL0000080116 classical genetics null chsB::argB conidiation: decreased disruptants do not form aerial hyphae, conidiophores, or conidia A. fumigatus Afu4g04180 ORF chsB ASPL0000106236 PMID: 8953267|AspGD_REF: ASPL0000080116 classical genetics null chsB::argB conidial germination: decreased rate A. fumigatus Afu4g04180 ORF chsB ASPL0000106236 PMID: 8953267|AspGD_REF: ASPL0000080116 classical genetics null chsB::argB colony size: decreased described as minute colonies A. fumigatus Afu4g04180 ORF chsB ASPL0000106236 PMID: 8953267|AspGD_REF: ASPL0000080116 classical genetics null chsB::argB hyphal growth: abnormal aberrant hyphae show a pattern of repetitive bulges along the hyphal walls A. fumigatus Afu4g04630 ORF ASPL0000106280 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance) viability: decreased mutants were killed following storage for 2 mo at room temperature in the absence of aeration, no difference in viability of conidia observed under aerated conditions A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16804168|AspGD_REF: ASPL0000111336 classical genetics null ecm33::pyr4 resistance to chemicals: increased caspofungin A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16804168|AspGD_REF: ASPL0000111336 classical genetics null ecm33::pyr4 viable A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16804168|AspGD_REF: ASPL0000111336 classical genetics null ecm33::pyr4 resistance to chemicals: increased Congo Red A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16804168|AspGD_REF: ASPL0000111336 classical genetics null ecm33::pyr4 conidial germination: increased rate A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16804168|AspGD_REF: ASPL0000111336 classical genetics null ecm33::pyr4 virulence: increased immunosuppressed mouse intravenous infection (cyclophosphamide immunosupression) A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null ecm33::phl (phleomycin resistance) conidial germination: increased rate A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null ecm33::phl (phleomycin resistance) viable A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null ecm33::phl (phleomycin resistance) resistance to killing by host cells: decreased human monocyte-derived macrophages A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null ecm33::phl (phleomycin resistance) resistance to phagocytosis: decreased human monocyte-derived macrophages A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 20656913|AspGD_REF: ASPL0000111232 classical genetics null ecm33::phl (phleomycin resistance) virulence: normal immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance marker) resistance to chemicals: decreased polyoxin D (chitin synthesis inhibitor) A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance marker) cell size: increased conidial diameter of the mutant was 1.6 times greater than wild-type A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance marker) resistance to chemicals: decreased nikkomycin (chitin synthesis inhibitor) A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance marker) resistance to killing by host cells: increased conidia but not mycelia were able to survive killing by mouse alveolar macrophages and PMNs better than WT controls A. fumigatus Afu4g06820 ORF ecm33 ASPL0000106396 PMID: 16672465|AspGD_REF: ASPL0000111259 classical genetics null ecm33::phl (phleomycin resistance marker) resistance to killing by host cells: decreased mutant germ tubes were more sensitive to killing by human neutrophils than those of the wild-type controls A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 19888672|AspGD_REF: ASPL0000111461 classical genetics gain of function cyp51A(M220I, G54R) (drug resistant alleles) resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15855543|AspGD_REF: ASPL0000111209 classical genetics gain of function cyp51A(M220I, G54R) resistance to chemicals: increased itraconazole M220 and G54 substitutions lead to increased azole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 12543662|AspGD_REF: ASPL0000111390 classical genetics gain of function cyp51A(G54R, G54W) resistance to chemicals: increased posaconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15215142|AspGD_REF: ASPL0000111387 classical genetics gain of function cyp51A(M220V, M220K, or M220T) resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 20055745|AspGD_REF: ASPL0000111459 classical genetics gain of function cyp51A(G448S) resistance to chemicals: increased itraconazole|voriconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 19225980|AspGD_REF: ASPL0000111466 classical genetics gain of function cyp51A(G448S) resistance to chemicals: increased voriconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 19225980|AspGD_REF: ASPL0000111466 classical genetics gain of function cyp51A(G448S) resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 17034993|AspGD_REF: ASPL0000111384 classical genetics gain of function cyp51A(G138C) resistance to chemicals: increased itraconazole mutant isolate obtained from a patient who received long-term treatment with itraconazole and voriconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 17034993|AspGD_REF: ASPL0000111384 classical genetics gain of function cyp51A(G138C) resistance to chemicals: increased voriconazole mutant isolate obtained from a patient who received long-term treatment with itraconazole and voriconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 18474574|AspGD_REF: ASPL0000111561 classical genetics gain of function cyp51A(G54E), G54V, G54R, G54W, M220V, M220K, M220T, M220I, F46Y, M172V, E426K and N248K resistance to chemicals: increased azoles itraconazole, voriconazole, ravuconazole, and posaconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 18644959|AspGD_REF: ASPL0000111380 systematic mutation set gain of function cyp51A(M220K) resistance to chemicals: increased azoles A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 11418514|AspGD_REF: ASPL0000081653 classical genetics overexpression resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 20831364|AspGD_REF: ASPL0000114484 classical genetics null cyp51A[G54E] (G54E, G54V, G54W, G54R, M220V, M220K, M220T, M220I) resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 17371828|AspGD_REF: ASPL0000111326 classical genetics gain of function cyp51A-(L98H) (drug resistant point mutant that also contains two copies of a 34-bp sequence in tandem in the promoter) resistance to chemicals: increased triazoles A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 21690285|AspGD_REF: ASPL0000166331 classical genetics gain of function cyp51A(TR/L98H) resistance to chemicals: increased triazoles A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15504870|AspGD_REF: ASPL0000111342 classical genetics gain of function cyp51A(N22D or M220I) (mutant alleles used as selectable markers for itraconazole resistance) resistance to chemicals: increased itraconazole A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15855543|AspGD_REF: ASPL0000111209 classical genetics null viable A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15917566|AspGD_REF: ASPL0000111210 classical genetics null viable A. fumigatus Afu4g06890 ORF cyp51A ASPL0000106403 PMID: 15917566|AspGD_REF: ASPL0000111210 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu4g07110 ORF ASPL0000106425 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g07190 ORF argB ASPL0000106433 PMID: 15365692|AspGD_REF: ASPL0000111197 classical genetics null argB::pyrG auxotrophy arginine A. fumigatus Afu4g07190 ORF argB ASPL0000106433 PMID: 15365692|AspGD_REF: ASPL0000111197 classical genetics null argB::pyrG viable A. fumigatus Afu4g07190 ORF argB ASPL0000106433 PMID: 14727059|AspGD_REF: ASPL0000111355 classical genetics null argB::1-pyrG (1-pyr4 transposon) auxotrophy arginine A. fumigatus Afu4g07190 ORF argB ASPL0000106433 PMID: 14727059|AspGD_REF: ASPL0000111355 classical genetics null argB::1-pyrG (1-pyr4 transposon) viable A. fumigatus Afu4g07570 ORF ASPL0000106472 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g07730 ORF ASPL0000106488 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g07800 ORF ASPL0000106495 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g08510 ORF triA ASPL0000106565 PMID: 19883779|AspGD_REF: ASPL0000089709 classical genetics null inviable inviability confirmed by heterokaryon rescue technique A. fumigatus Afu4g09050 ORF atg1 ASPL0000106620 PMID: 17921348|AspGD_REF: ASPL0000113296 classical genetics null atg1::HygR autophagy: decreased A. fumigatus Afu4g09050 ORF atg1 ASPL0000106620 PMID: 17921348|AspGD_REF: ASPL0000113296 classical genetics null atg1::HygR viable A. fumigatus Afu4g09050 ORF atg1 ASPL0000106620 PMID: 17921348|AspGD_REF: ASPL0000113296 classical genetics null atg1::HygR virulence: normal C57BL/6 mice immunosuppressed mouse pulmonary infection (neutropenia was induced by the monoclonal antibody RB6-8C5 and cyclohexamide; cortisone acetate also used as a mode of immunosuppression) A. fumigatus Afu4g09420 ORF cafC ASPL0000106657 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafC::pyrG viable A. fumigatus Afu4g09420 ORF cafC ASPL0000106657 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (low-dose model) A. fumigatus Afu4g09420 ORF cafC ASPL0000106657 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafC::pyrG conidiation: decreased Minimal medium (MM) at both 5% and 0.033% CO2 A. fumigatus Afu4g09710 ORF rosA ASPL0000106685 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased sodium dodecyl sulfate (0.014%) A. fumigatus Afu4g09710 ORF rosA ASPL0000106685 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null RNA accumulation: increased pmcB mRNA A. fumigatus Afu4g09710 ORF rosA ASPL0000106685 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null viable A. fumigatus Afu4g09710 ORF rosA ASPL0000106685 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased itraconazole A. fumigatus Afu4g09710 ORF rosA ASPL0000106685 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased caspofungin A. fumigatus Afu4g09740 ORF ASPL0000106688 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null htfA::pyrG viable A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null htfA::pyrG RNA accumulation: decreased pmcA mRNA A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased sodium dodecyl sulfate (0.014%) A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased itraconazole A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased caspofungin A. fumigatus Afu4g10110 ORF htfA ASPL0000106725 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null htfA::pyrG RNA accumulation: decreased pmcB mRNA A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564385|AspGD_REF: ASPL0000111245 classical genetics null prtT::HygR protein activity: decreased secreted protease A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564385|AspGD_REF: ASPL0000111245 classical genetics null prtT::HygR virulence: normal secreted protease immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression or cortisone acetate only immunosuppression) A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564385|AspGD_REF: ASPL0000111245 classical genetics null prtT::HygR viable A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564390|AspGD_REF: ASPL0000111102 classical genetics null prtT::loxP-PhleoR-loxP virulence: normal immunosuppressed mouse pulmonary infection (low dose model) A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564390|AspGD_REF: ASPL0000111102 classical genetics null prtT::loxP-PhleoR-loxP viable A. fumigatus Afu4g10120 ORF prtT ASPL0000106726 PMID: 19564390|AspGD_REF: ASPL0000111102 classical genetics null prtT::loxP-PhleoR-loxP utilization of nitrogen source: decreased BSA as the sole source of nitrogen clear growth retardation was observed, near absence of mycelial expansion A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20363898|AspGD_REF: ASPL0000111084 classical genetics null viable A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20363898|AspGD_REF: ASPL0000111084 classical genetics null auxotrophy lysine A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20363898|AspGD_REF: ASPL0000111084 classical genetics null virulence: decreased virulence was partially restored by lysine supplementation in the drinking water immunosuppressed mouse pulmonary infection (5 wk old female specific-pathogen-free outbred CD-1 mice; cortisone acetate immunosuppression) A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20363898|AspGD_REF: ASPL0000111084 classical genetics null virulence: normal virulence was partially restored by lysine supplementation in the drinking water immunosuppressed mouse intravenous infection (5 wk old female specific-pathogen-free outbred CD-1 mice; cortisone acetate immunosuppression) A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20421382|AspGD_REF: ASPL0000112821 classical genetics null virulence: decreased strongly attenuated in eggs infected via the CAM on developmental day 10, irrespective of the infectious dose other model (embryonated chick eggs) A. fumigatus Afu4g10460 ORF hcsA ASPL0000106760 PMID: 20421382|AspGD_REF: ASPL0000112821 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu4g10770 ORF ppoA ASPL0000106790 PMID: 16040966|AspGD_REF: ASPL0000078953 classical genetics null chemical compound accumulation: decreased prostoglandin A. fumigatus Afu4g10770 ORF ppoA ASPL0000106790 PMID: 17906293|AspGD_REF: ASPL0000079361 classical genetics null chemical compound accumulation: absent (5S,8R)-dihydroxy-9Z,12Z-octadecadienoic acid A. fumigatus Afu4g11240 ORF aarA ASPL0000106833 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g11250 ORF cafA ASPL0000106834 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafA::pyrG viable A. fumigatus Afu4g11250 ORF cafA ASPL0000106834 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafA::pyrG conidiation: decreased Minimal medium (MM) at both 5% and 0.033% CO2 A. fumigatus Afu4g11250 ORF cafA ASPL0000106834 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafA::pyrG virulence: normal immunosuppressed mouse pulmonary infection (low-dose model) A. fumigatus Afu4g11280 ORF ASPL0000106837 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible colony size: decreased A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible alcA(p)-srb1 conidiation: decreased morphologically normal conidia A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible alcA(p)-srb1 resistance to chemicals: decreased sodium dodecyl sulfate (0.01%) A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible alcA(p)-srb1 resistance to chemicals: decreased Congo Red (150 micrograms/ml) A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible alcA(p)-srb1 resistance to chemicals: decreased G418 (40 micrograms/ml) A. fumigatus Afu4g11510 ORF srb1 ASPL0000106859 PMID: 18757806|AspGD_REF: ASPL0000111250 classical genetics repressible alcA(p)-srb1 resistance to chemicals: decreased hygromycin B (20 micrograms/ml) A. fumigatus Afu4g11580 ORF sod2 ASPL0000106866 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null sod2::HPH resistance to chemicals: decreased menadione A. fumigatus Afu4g11580 ORF sod2 ASPL0000106866 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null sod2::HPH viable A. fumigatus Afu4g11580 ORF sod2 ASPL0000106866 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null sod2::HPH thermotolerance: decreased YPD agar medium growth was inhibited at 45 degrees C and at 50 degrees C A. fumigatus Afu4g11800 ORF alp1 ASPL0000106888 PMID: 1495393|AspGD_REF: ASPL0000111556 classical genetics null protein activity: decreased elastase A. fumigatus Afu4g11800 ORF alp1 ASPL0000106888 PMID: 1495393|AspGD_REF: ASPL0000111556 classical genetics null viable A. fumigatus Afu4g11800 ORF alp1 ASPL0000106888 PMID: 1495393|AspGD_REF: ASPL0000111556 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (inhalation model) A. fumigatus Afu4g11800 ORF alp1 ASPL0000106888 PMID: 1495393|AspGD_REF: ASPL0000111556 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (intranasal model) A. fumigatus Afu4g12470 ORF cpcA ASPL0000106954 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null viable A. fumigatus Afu4g12470 ORF cpcA ASPL0000106954 PMID: 20370364|AspGD_REF: ASPL0000111240 classical genetics null virulence: decreased insect infection (Toll-deficient flies) A. fumigatus Afu4g12470 ORF cpcA ASPL0000106954 PMID: 15101984|AspGD_REF: ASPL0000078877 classical genetics null cpcA::phleo viable A. fumigatus Afu4g12470 ORF cpcA ASPL0000106954 PMID: 15101984|AspGD_REF: ASPL0000078877 classical genetics null cpcA::phleo competitive fitness: decreased outbred 20 to 28 g male mice mixed infection experiment with wild type strain immunosuppressed mouse pulmonary infection (hydrocortisone acetate and cyclophosphamide immunosuppression) A. fumigatus Afu4g12470 ORF cpcA ASPL0000106954 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG viable A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG hyphal growth: abnormal reduced hyphal branching A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG conidiation: decreased A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG viability: decreased decreased spore viability A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG conidial germination: delayed A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG conidiation: decreased A. fumigatus Afu4g13230 ORF wetA ASPL0000107029 PMID: 20966095|AspGD_REF: ASPL0000112692 classical genetics null wetA::AnpyrG RNA accumulation: decreased vosA mRNA A. fumigatus Afu4g13510 ORF acuD ASPL0000107057 PMID: 17178786|AspGD_REF: ASPL0000113881 classical genetics null acuD::hph viable A. fumigatus Afu4g13510 ORF acuD ASPL0000107057 PMID: 17178786|AspGD_REF: ASPL0000113881 classical genetics null acuD::hph virulence: normal immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu4g13510 ORF acuD ASPL0000107057 PMID: 17616408|AspGD_REF: ASPL0000113782 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG viable A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased Congo Red (20 mg/L) A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased Calcofluor White (300 mg/L) A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased sodium dodecyl sulfate (0.007%) A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased diamide A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased menadione A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: increased hydrogen peroxide A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG resistance to chemicals: decreased caffeine phenotype only observed with 5 mM caffeine A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG colony size: decreased 4 days on AMM medium at 37 degree C A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG hyphal growth: abnormal thicker, more highly branched hyphae than wild-type A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 17981060|AspGD_REF: ASPL0000111323 classical genetics null mpkA::pyrG virulence: delayed survival of mice infected with mutant same as those infected with wild-type after 2 weeks post-infection A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null viable A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null colony size: decreased A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to enzymatic treatment: decreased Glucanex, a compound with high chitinase and glucanase activity; sensitivity overcome by addition of 1 M sorbitol to the medium A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null hyphal growth: abnormal abnormal hyphal structures with elevated branching frequency A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased sodium dodecyl sulfate phenotype reversed by high osmolarity medium A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Congo Red A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null resistance to chemicals: decreased Calcofluor White A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null thermotolerance: decreased not able to grow at 48 degrees C ; phenotype reversed by addition of 1 M sorbitol to the medium A. fumigatus Afu4g13720 ORF mpkA ASPL0000107078 PMID: 19715768|AspGD_REF: ASPL0000111100 classical genetics null protein activity: decreased HmgA A. fumigatus Afu4g14770 ORF osc3 ASPL0000107181 PMID: 19951700|AspGD_REF: ASPL0000111095 classical genetics unspecified osc3[OSPC-A702N] (residues APPGGMR (702-708) were replaced with NKSCAIS) chemical compound accumulation: decreased protostadienol A. fumigatus Afu5g00760 ORF chsC ASPL0000107260 PMID: 8736545|AspGD_REF: ASPL0000111281 classical genetics null chsC::HygR viable A. fumigatus Afu5g00760 ORF chsC ASPL0000107260 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein/peptide accumulation: normal beta-1,3-glucan A. fumigatus Afu5g00760 ORF chsC ASPL0000107260 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein activity: decreased chitin synthase A. fumigatus Afu5g00760 ORF chsC ASPL0000107260 PMID: 21763289|AspGD_REF: ASPL0000166457 classical genetics null protein/peptide accumulation: normal chitin A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG protein/peptide modification: increased slightly increased H3K9 methylation H3K9 A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG viable A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG secondary metabolite production: increased sterigmatocystin A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG secondary metabolite production: increased penicillin A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG colony size: decreased slightly decreased radial growth on GMM and CYA media A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG conidial germination: delayed A. fumigatus Afu5g01980 ORF hdaA ASPL0000107378 PMID: 19563902|AspGD_REF: ASPL0000111103 classical genetics null hdaA::pyrG resistance to phagocytosis: normal in vitro model of infection (MH-S and RAW 264.7 cell lines) A. fumigatus Afu5g02330 ORF aspf1 ASPL0000107413 PMID: 8359677|AspGD_REF: ASPL0000111368 classical genetics null aspf1::hph viable A. fumigatus Afu5g02330 ORF aspf1 ASPL0000107413 PMID: 8359677|AspGD_REF: ASPL0000111368 classical genetics null aspf1::hph virulence: normal immunosuppressed mouse pulmonary infection (cortisone immunosupression) A. fumigatus Afu5g02370 ORF ASPL0000107417 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g02450 ORF erg20 ASPL0000107425 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g03560 ORF ASPL0000107534 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g03760 ORF chiA1 ASPL0000107554 PMID: 21184840|AspGD_REF: ASPL0000164318 classical genetics null chiA1::PYRG viable A. fumigatus Afu5g03760 ORF chiA1 ASPL0000107554 PMID: 21184840|AspGD_REF: ASPL0000164318 classical genetics null chiA1::PYRG autolysis: decreased 5 wks of shaking culture (150 rpm) in Sabouraud medium at 37 degrees C dry weight of mycelia measured A. fumigatus Afu5g03760 ORF chiA1 ASPL0000107554 PMID: 21184840|AspGD_REF: ASPL0000164318 classical genetics null chiA1::PYRG protein activity: decreased specific chitinase activity in resting and germinating conidia chitinase A. fumigatus Afu5g03800 ORF ftrA ASPL0000107558 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null ftrA::hph viable A. fumigatus Afu5g03800 ORF ftrA ASPL0000107558 PMID: 15504822|AspGD_REF: ASPL0000111199 classical genetics null ftrA::hph virulence: normal immunosuppressed mouse pulmonary infection (18?22 g CD1 male mice) A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null conidiation: decreased during iron starvation A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null viable A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null chemical compound accumulation: decreased ferricrocin|triacetylfusarinine C A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null virulence: decreased immunosuppressed mouse pulmonary infection (non-leucopenic model with immunosuppression by cortisone acetate) A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null chemical compound accumulation: increased protoporphyrin IX causes reddish pigmentation A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null RNA accumulation: decreased sidG mRNA A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null resistance to chemicals: decreased zinc decreased zinc resistance during iron starvation A. fumigatus Afu5g03920 ORF hapX ASPL0000107570 PMID: 20941352|AspGD_REF: ASPL0000164710 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (leucopenic mouse model using immunosuppression with cortisone acetate and cyclophosphamide) A. fumigatus Afu5g05480 ORF rhbA ASPL0000107627 PMID: 12704156|AspGD_REF: ASPL0000111266 classical genetics null rhbA::HygR viable A. fumigatus Afu5g05480 ORF rhbA ASPL0000107627 PMID: 12704156|AspGD_REF: ASPL0000111266 classical genetics null rhbA::HygR conidiation: increased conidiates under submerged culture A. fumigatus Afu5g05480 ORF rhbA ASPL0000107627 PMID: 12704156|AspGD_REF: ASPL0000111266 classical genetics null rhbA::HygR resistance to chemicals: decreased rapamycin A. fumigatus Afu5g05480 ORF rhbA ASPL0000107627 PMID: 12704156|AspGD_REF: ASPL0000111266 classical genetics null rhbA::HygR virulence: decreased 20 to 24 g female CF-1 outbred mice immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu5g05920 ORF ASPL0000107669 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g06750 ORF cpcC ASPL0000107751 PMID: 18249572|AspGD_REF: ASPL0000111494 classical genetics null cpcC::loxP-phleo viable A. fumigatus Afu5g06750 ORF cpcC ASPL0000107751 PMID: 18249572|AspGD_REF: ASPL0000111494 classical genetics null cpcC::loxP-phleo starvation resistance: decreased amino acid A. fumigatus Afu5g07390 ORF ASPL0000107813 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g07740 ORF akuA ASPL0000107846 PMID: 16400185|AspGD_REF: ASPL0000111261 classical genetics null akuA::ptrA (pyrithiamine resistance marker) viable A. fumigatus Afu5g07740 ORF akuA ASPL0000107846 PMID: 16400185|AspGD_REF: ASPL0000111261 classical genetics null akuA::ptrA virulence: normal insect infection (Galleria mellonella larvae) A. fumigatus Afu5g07770 ORF ASPL0000107849 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g07780 ORF erg1 ASPL0000107850 PMID: 15215099|AspGD_REF: ASPL0000111346 classical genetics overexpression resistance to chemicals: increased terbinafine A. fumigatus Afu5g07780 ORF erg1 ASPL0000107850 PMID: 16801438|AspGD_REF: ASPL0000079297 classical genetics unspecified erg1(F389L) resistance to chemicals: increased terbinafine A. fumigatus Afu5g08370 ORF ASPL0000107909 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG colony size: decreased retarded growth A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG conidial germination: delayed extended isotropic growth of germinating conidia followed by multiple germ tubes and wide hyphae with short intercalary cells A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG hyphal growth: abnormal multiple subapical branches and wide hyphae with short intercalary cells A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG RNA accumulation: decreased no effect on expression when strains were cultured at 37 degrees C for 6h; at 17h, the expression of rho4 was decreased to 0.33-fold rho4 A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG RNA accumulation: decreased no effect on expression when strains were cultured at 37 degrees C for 6h; at 17h, the expression of rho1 was decreased 0.18-fold rho1 A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG vesicle distribution: abnormal A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG actin cytoskeleton morphology: abnormal actin patches were distributed randomly at low density in the mutant at early stages of development, later reaggregating at the hyphal tip when the germ tube extended to form long filaments A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG formation of anatomical structure: abnormal conidiophore A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 21796487|AspGD_REF: ASPL0000166475 classical genetics null sho1::pyrG RNA accumulation: decreased no effect on expression when strains were cultured at 37 degrees C for 6h; at 17h, the expression of rho3 was decreased to 0.18-fold rho3 A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG viable A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG colony size: decreased A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG conidial germination: delayed A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG resistance to chemicals: decreased hydrogen peroxide (2.5 mM) A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG resistance to chemicals: decreased menadione (15 micromolar) A. fumigatus Afu5g08420 ORF sho1 ASPL0000107913 PMID: 18227163|AspGD_REF: ASPL0000111148 classical genetics null sho1::pyrG virulence: normal immunosuppressed mouse pulmonary infection (6 wk old BALB/c male mice) A. fumigatus Afu5g08570 ORF pkaC2 ASPL0000107928 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC2;;phleo viable A. fumigatus Afu5g08570 ORF pkaC2 ASPL0000107928 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC2;;phleo conidiation: normal A. fumigatus Afu5g08570 ORF pkaC2 ASPL0000107928 PMID: 21210869|AspGD_REF: ASPL0000166185 classical genetics null pkaC2;;phleo formation of anatomical structure: abnormal mutants are underdeveloped or display aberrant morphologies conidiophore A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 20586114|AspGD_REF: ASPL0000111234 classical genetics null och1::hph|och1::loxble viable A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 20586114|AspGD_REF: ASPL0000111234 classical genetics null adhesion: increased increased cell clumping A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 21206755|AspGD_REF: ASPL0000165816 classical genetics null och1::hph viable A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 21206755|AspGD_REF: ASPL0000165816 classical genetics null och1::hph conidiation: decreased conidiation of the mutant was reduced in the presence of high calcium concentrations A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 21206755|AspGD_REF: ASPL0000165816 classical genetics null och1::hph virulence: increased slightly higher virulence were observed in the intranasal infection model immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 21206755|AspGD_REF: ASPL0000165816 classical genetics null och1::hph virulence: increased significantly faster killing of mice occured in the systemic model of infection other model (retroorbital inoculation) A. fumigatus Afu5g08580 ORF och1 ASPL0000107929 PMID: 21206755|AspGD_REF: ASPL0000165816 classical genetics null och1::hph induction of host response: normal normal TNF alpha cytokine response in infected murine peritoneal macrophages A. fumigatus Afu5g08890 ORF lysF ASPL0000107960 PMID: 15052376|AspGD_REF: ASPL0000079526 classical genetics null lysF::hygR auxotrophy lysine A. fumigatus Afu5g08890 ORF lysF ASPL0000107960 PMID: 15052376|AspGD_REF: ASPL0000079526 classical genetics null lysF::hygR virulence: decreased 16-20g female BALB/c mice immunosuppressed mouse pulmonary infection (low-dose infection model; cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu5g08890 ORF lysF ASPL0000107960 PMID: 15052376|AspGD_REF: ASPL0000079526 classical genetics null lysF::hygR viable A. fumigatus Afu5g09100 ORF mpkC ASPL0000107981 PMID: 21627838|AspGD_REF: ASPL0000166234 classical genetics null resistance to chemicals: decreased benzaldehydes A. fumigatus Afu5g09100 ORF mpkC ASPL0000107981 PMID: 20943191|AspGD_REF: ASPL0000112699 classical genetics null resistance to chemicals: decreased benzoic acid 3 to 3.5 mM benzoic acid benzoic acids and structural acids inhibit growth of mpkC mutants A. fumigatus Afu5g09100 ORF mpkC ASPL0000107981 PMID: 16998074|AspGD_REF: ASPL0000079014 classical genetics null mpkC::pyrG viable A. fumigatus Afu5g09100 ORF mpkC ASPL0000107981 PMID: 16998074|AspGD_REF: ASPL0000079014 classical genetics null mpkC::pyrG utilization of carbon source: decreased mannitol|sorbitol A. fumigatus Afu5g09100 ORF mpkC ASPL0000107981 PMID: 16998074|AspGD_REF: ASPL0000079014 classical genetics null mpkC::pyrG conidial germination: decreased mutant germinates poorly in MM-sorbitol A. fumigatus Afu5g09210 ORF alp2 ASPL0000107990 PMID: 11100830|AspGD_REF: ASPL0000111398 classical genetics null conidiation: decreased more than 80% reduction in conidia production A. fumigatus Afu5g09210 ORF alp2 ASPL0000107990 PMID: 11100830|AspGD_REF: ASPL0000111398 classical genetics null viable A. fumigatus Afu5g09210 ORF alp2 ASPL0000107990 PMID: 11100830|AspGD_REF: ASPL0000111398 classical genetics null vegetative growth: decreased rate A. fumigatus Afu5g09210 ORF alp2 ASPL0000107990 PMID: 11100830|AspGD_REF: ASPL0000111398 classical genetics null formation of anatomical structure: abnormal approximately 50% reduction of the median diameter of conidiophore vesicles conidiophore vesicle A. fumigatus Afu5g09240 ORF sod1 ASPL0000107993 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null viable A. fumigatus Afu5g09240 ORF sod1 ASPL0000107993 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null sod1::HPH resistance to chemicals: decreased menadione A. fumigatus Afu5g09240 ORF sod1 ASPL0000107993 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null sod1::HPH thermotolerance: decreased growth was inhibited at 45 and 50 degrees C on YPD agar medium A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16400184|AspGD_REF: ASPL0000111161 classical genetics null colony size: decreased A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16400184|AspGD_REF: ASPL0000111161 classical genetics null hyphal growth: decreased increased hyphal branching A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 18606829|AspGD_REF: ASPL0000111252 classical genetics null colony size: decreased A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null RNA accumulation: increased aoxA mRNA A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null RNA accumulation: increased htfA mRNA A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null RNA accumulation: increased zfpB mRNA A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null viable A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null viable A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased echinochandins (caspofungin, micafungin and anidulafungin) A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 17502415|AspGD_REF: ASPL0000079990 classical genetics null chemical compound accumulation: decreased beta-D-glucan A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 18298443|AspGD_REF: ASPL0000079773 classical genetics null RNA accumulation: decreased brlA mRNA A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16990036|AspGD_REF: ASPL0000079011 classical genetics null calA::pyrG viable A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16990036|AspGD_REF: ASPL0000079011 classical genetics null calA::pyrG vegetative growth: decreased rate A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16990036|AspGD_REF: ASPL0000079011 classical genetics null calA::pyrG virulence: decreased other model A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16990036|AspGD_REF: ASPL0000079011 classical genetics null calA::pyrG formation of anatomical structure: abnormal conidium A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG filamentous growth: decreased hyphae appear compact, more dense, and extremely blunted A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG conidiation: decreased A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16990036|AspGD_REF: ASPL0000079011 classical genetics null calA::pyrG resistance to chemicals: increased cyclosporin A (also tested Sirolimus, Tacrolimus) A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG viable A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG formation of anatomical structure: abnormal conidia without rodlets conidium A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG virulence: decreased mouse pulmonary infection A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 16835453|AspGD_REF: ASPL0000079005 classical genetics null calA::pyrG virulence: decreased immunosuppressed mouse pulmonary infection A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased nikkomycin Z large, balloon-like cells with greatly decreased hyphal formation following 1 microgram/ml nikkomycin Z treatment A. fumigatus Afu5g09360 ORF calA ASPL0000108005 PMID: 21107627|AspGD_REF: ASPL0000115811 classical genetics null protein activity: decreased beta-galactofuranosidase A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 12620846|AspGD_REF: ASPL0000079464 classical genetics null resistance to killing by host cells: decreased alveolar macrophages from infected male outbred Swiss OF1 mice A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 7927699|AspGD_REF: ASPL0000082498 classical genetics null rodA::hph viable A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 7927699|AspGD_REF: ASPL0000082498 classical genetics null rodA::hph adhesion: normal alveolar type II cells isolated from the lungs of adult Sprague-Dawley rats A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 7927699|AspGD_REF: ASPL0000082498 classical genetics null rodA::hph colony color: abnormal mutant colonies looked darker than wild-type colonies A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 7927699|AspGD_REF: ASPL0000082498 classical genetics null rodA::hph virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu5g09580 ORF rodA ASPL0000108027 PMID: 7927699|AspGD_REF: ASPL0000082498 classical genetics null rodA::hph adhesion: normal adherence to collagen, human fibrinogen, laminin, and bovine serum albumin tested A. fumigatus Afu5g09750 ORF azgA ASPL0000108044 PMID: 17881254|AspGD_REF: ASPL0000081382 classical genetics null viable A. fumigatus Afu5g09750 ORF azgA ASPL0000108044 PMID: 17881254|AspGD_REF: ASPL0000081382 classical genetics null resistance to chemicals: increased 8-azaguanine A. fumigatus Afu5g10740 ORF ASPL0000108136 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g10750 ORF ASPL0000108137 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 20398212|AspGD_REF: ASPL0000112872 classical genetics null resistance to chemicals: decreased farnesol (20um to 1 mM) growth only partially restored by sorbitol A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 20398212|AspGD_REF: ASPL0000112872 classical genetics null resistance to chemicals: decreased cytochalasin A A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk viable A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk virulence: decreased male CD-1 and B6.CD45.1 mice other model (retroorbital infection of mice) A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk resistance to chemicals: decreased posoconazole A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk resistance to chemicals: decreased voriconazole A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk resistance to chemicals: decreased Calcofluor White (60 micrograms/ml) A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk resistance to chemicals: decreased Congo Red (30 micrograms/ml) A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk conidial germination: abnormal short germ tubes characterized by amorphous structures at the terminal tips A. fumigatus Afu5g10760 ORF mnt1 ASPL0000108138 PMID: 18708564|AspGD_REF: ASPL0000111137 classical genetics null mnt1::hph/tk formation of anatomical structure: absent mutant still forms vesicles and phialides conidium A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasA (G17V) conidiation: decreased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasA (G17V) colony color: abnormal due to reduced amount of conidia produced A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasA (G17V) conidial germination: abnormal 6hr germinating conidia were more swollen and had longer germ tubes relative to wild-type A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasA (S22N) conidial germination: decreased rate A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasA (G17V) formation of anatomical structure: abnormal minimally swollen vesicles with irregular phialides conidiophore A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics activation rasA (G17V) formation of anatomical structure: delayed conidiophore A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 14732259|AspGD_REF: ASPL0000079436 classical genetics dominant negative rasA (S22N) mitotic cell cycle: increased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null viable A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: decreased nikkomycin Z large, balloon-like cells with greatly decreased hyphal formation following 1 microgram/ml nikkomycin Z treatment A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics null resistance to chemicals: increased echinochandins (caspofungin, micafungin and anidulafungin) A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 19015336|AspGD_REF: ASPL0000111310 classical genetics activation resistance to chemicals: decreased echinochandins (caspofungin, micafungin and anidulafungin) A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null colony size: decreased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null conidiation: decreased phenotype remediated by 1.2 M sorbitol A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null conidial germination: decreased rate A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null hyphal growth: abnormal mutant hyphae were more than twice the diameter of wild-type hyphae A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null resistance to enzymatic treatment: increased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null resistance to chemicals: decreased Congo Red (75 microgram/ml) mutant forms large swollen cells with no polarized growth axis A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null resistance to chemicals: decreased sodium dodecyl sulfate A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null resistance to chemicals: decreased Fungin A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 18606827|AspGD_REF: ASPL0000081356 classical genetics null resistance to chemicals: decreased caffeine (3 mM) A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics activation rasA (G17V) colony size: decreased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics overexpression pOtef-RasA conidiation: decreased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics null colony size: decreased A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics activation rasA (G17V) cell lysis: increased lysis observed in germinating conidia A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics activation rasA (G17V) vacuolar morphology: abnormal abberant vacuolar accumulation and expansion A. fumigatus Afu5g11230 ORF rasA ASPL0000108182 PMID: 21278230|AspGD_REF: ASPL0000164399 classical genetics activation hyphal growth: abnormal abortive growth axes and subapical hyphal compartments that undergo excessive swelling and vacuolization A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 21622789|AspGD_REF: ASPL0000166219 classical genetics null RNA accumulation: increased low iron conditions mirB mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph viable A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph colony color: abnormal orange colonies A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph RNA accumulation: increased sidA mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph RNA accumulation: increased fetC mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph RNA accumulation: increased ftrA mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph RNA accumulation: increased cat1 mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph RNA accumulation: increased cccA mRNA A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph metal resistance: decreased iron(2+) FeSO4 A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph virulence: normal immunosuppressed mouse pulmonary infection (low-dose) A. fumigatus Afu5g11260 ORF sreA ASPL0000108185 PMID: 18721228|AspGD_REF: ASPL0000111136 classical genetics null sreA::hph oxidative stress resistance: decreased menadione A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null viable A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null colony size: decreased ~1.0% the size of WT controls, phenotype not restored by high osmolarity A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null vegetative growth: delayed submerged culture A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null conidiation: increased about a 2-fold increase on plates based on equivalent sized colony sections; increased conidiophore development in submerged culture A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null secondary metabolite production: decreased gliotoxin A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null RNA accumulation: increased gliotoxin brlA mRNA A. fumigatus Afu5g12210 ORF sfaD ASPL0000108277 PMID: 19915845|AspGD_REF: ASPL0000111299 classical genetics null RNA accumulation: delayed gliotoxin gliZ mRNA A. fumigatus Afu5g12680 ORF ASPL0000108322 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null resistance to chemicals: decreased voriconazole A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null resistance to chemicals: increased diamide A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null conidial germination: decreased A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null viable A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null induction of host response: decreased host cells secrete decreased levels of TNF-alpha, IL-6, RANTES and IL-10 A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null virulence: increased insect infection (G. mellonella larvae) A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null virulence: increased immunosuppressed mouse pulmonary infection (hydrocortisone acetate immunosupression) A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu5g12730 ORF nrps8 ASPL0000108327 PMID: 21746855|AspGD_REF: ASPL0000166434 classical genetics null hyphal growth: abnormal mutants make shorter hyphae than wild-type A. fumigatus Afu5g12820 ORF ASPL0000108336 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g13120 ORF ASPL0000108365 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu5g13300 ORF pep1 ASPL0000108383 PMID: 9229335|AspGD_REF: ASPL0000111366 classical genetics null virulence: normal mouse pulmonary infection A. fumigatus Afu5g13300 ORF pep1 ASPL0000108383 PMID: 9229335|AspGD_REF: ASPL0000111366 classical genetics null virulence: normal guinea pig intravenous infection A. fumigatus Afu5g13300 ORF pep1 ASPL0000108383 PMID: 9229335|AspGD_REF: ASPL0000111366 classical genetics null viable A. fumigatus Afu6g01970 ORF ASPL0000108652 PMID: 9669338|AspGD_REF: ASPL0000081937 classical genetics null utilization of nitrogen source: decreased L-alanine, L-arginine, L-asparagine, L-aspartate, glycine, L-ornithine, L-proline, L-threonine, milk, collagen A. fumigatus Afu6g01970 ORF ASPL0000108652 PMID: 9669338|AspGD_REF: ASPL0000081937 classical genetics null virulence: delayed immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu6g01970 ORF ASPL0000108652 PMID: 9669338|AspGD_REF: ASPL0000081937 classical genetics null competitive fitness: decreased 6 days post-infection mutant strain constituted 46% of inoculum but only 19% of recovered isolates were mutant immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu6g01970 ORF ASPL0000108652 PMID: 9669338|AspGD_REF: ASPL0000081937 classical genetics null viable A. fumigatus Afu6g02230 ORF glkA ASPL0000108678 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null glkA::hph viable A. fumigatus Afu6g02230 ORF glkA ASPL0000108678 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null glkA::HygR viable A. fumigatus Afu6g02230 ORF glkA ASPL0000108678 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null glkA::HygR protein activity: increased isocitrate lyase A. fumigatus Afu6g02230 ORF glkA ASPL0000108678 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null glkA::HygR resistance to chemicals: decreased sodium dodecyl sulfate (0.01%) A. fumigatus Afu6g02230 ORF glkA ASPL0000108678 PMID: 20453072|AspGD_REF: ASPL0000164704 classical genetics null glkA::HygR conidial germination: delayed 0.1 mM glucose and 10 mM ethanol A. fumigatus Afu6g02460 ORF gup1 ASPL0000108701 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g03540 ORF acuE ASPL0000108809 PMID: 17616408|AspGD_REF: ASPL0000113782 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 16008561|AspGD_REF: ASPL0000081458 classical genetics null mcsA::pyrG (A. nidulans pyrG) viable A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 16008561|AspGD_REF: ASPL0000081458 classical genetics null mcsA::pyrG (A. nidulans pyrG) resistance to chemicals: decreased propionate A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 16008561|AspGD_REF: ASPL0000081458 classical genetics null mcsA::pyrG (A. nidulans pyrG) virulence: decreased insect infection (Galleria mellonella larvae) A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 16008561|AspGD_REF: ASPL0000081458 classical genetics null colony color: abnormal abnormal colony color, especially in the presence of 10 mM propionate A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 17973657|AspGD_REF: ASPL0000113273 classical genetics null mcsA::pyrG resistance to killing by host cells: decreased mutants killed more readily by alveolar macrophages than wild-type A. fumigatus Afu6g03590 ORF mcsA ASPL0000108814 PMID: 17973657|AspGD_REF: ASPL0000113273 classical genetics null mcsA::pyrG virulence: decreased immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu6g03890 ORF catA ASPL0000108844 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu6g03890 ORF catA ASPL0000108844 PMID: 12761140|AspGD_REF: ASPL0000078814 classical genetics null catA::phleo viable A. fumigatus Afu6g03890 ORF catA ASPL0000108844 PMID: 12761140|AspGD_REF: ASPL0000078814 classical genetics null catA::phleo resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu6g03890 ORF catA ASPL0000108844 PMID: 12761140|AspGD_REF: ASPL0000078814 classical genetics null catA::phleo resistance to killing by host cells: normal alveolar macrophages from immunocompetent mice A. fumigatus Afu6g04060 ORF ASPL0000108861 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19389762|AspGD_REF: ASPL0000111246 classical genetics null cwh41::pyrG protein secretion: increased Ecm33p A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19389762|AspGD_REF: ASPL0000111246 classical genetics null cwh41::pyrG protein secretion: increased Gel1p A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19389762|AspGD_REF: ASPL0000111246 classical genetics null cwh41::pyrG actin cytoskeleton morphology: abnormal no obvious actin patch accumulated at the hyphal tip of the mutant A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG viable A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG protein secretion: decreased ChiB A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG conidiation: decreased mutant produces about one half the conidia produced by wild-type A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG protein/peptide modification: decreased ChiB A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG resistance to chemicals: decreased Congo Red (250 micrograms/ml) 50 degrees C A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG resistance to chemicals: decreased Calcofluor White (250 micrograms/ml) slightly increased sensitivity to calcofluor white at 50 degrees C A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG septum formation: abnormal the first septum is formed randomly after germination A. fumigatus Afu6g04210 ORF cwh41 ASPL0000108875 PMID: 19090038|AspGD_REF: ASPL0000111135 classical genetics null cwh41::pyrG virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu6g04420 ORF ASPL0000108896 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g04610 ORF ASPL0000108915 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g04670 ORF derA ASPL0000108921 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null derA::ptrA viable A. fumigatus Afu6g04670 ORF derA ASPL0000108921 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null derA::ptrA heat sensitivity: normal 50 degrees C A. fumigatus Afu6g04670 ORF derA ASPL0000108921 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null derA::ptrA resistance to chemicals: normal Calcofluor White|Congo Red|brefeldin A|dithioerythritol A. fumigatus Afu6g04670 ORF derA ASPL0000108921 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null derA::ptrA virulence: normal infected lung tissue appears identical to wild-type immunosuppressed mouse pulmonary infection (triamcinolone acetonide immunosuppression; intranasal infection with conidia) A. fumigatus Afu6g04670 ORF derA ASPL0000108921 PMID: 21217201|AspGD_REF: ASPL0000165810 classical genetics null derA::ptrA RNA accumulation: increased bipA is constitutively elevated in the derA mutant indicating loss of derA is sufficient to increase the level of ER stress bipA mRNA A. fumigatus Afu6g04680 ORF mitA ASPL0000108922 PMID: 19822220|AspGD_REF: ASPL0000111099 classical genetics null mitA::hph/tk viable A. fumigatus Afu6g04680 ORF mitA ASPL0000108922 PMID: 19822220|AspGD_REF: ASPL0000111099 classical genetics null mitA::hph/tk resistance to chemicals: increased pyrithiamine A. fumigatus Afu6g04680 ORF mitA ASPL0000108922 PMID: 19822220|AspGD_REF: ASPL0000111099 classical genetics null mitA::hph/tk resistance to chemicals: decreased calcium(2+) (350 mM) sensitive to high Ca2+ concentrations A. fumigatus Afu6g04680 ORF mitA ASPL0000108922 PMID: 19822220|AspGD_REF: ASPL0000111099 classical genetics null mitA::hph/tk conidial germination: delayed defect especially noticeable at early stages of germination A. fumigatus Afu6g04680 ORF mitA ASPL0000108922 PMID: 19822220|AspGD_REF: ASPL0000111099 classical genetics null mitA::hph/tk virulence: normal retroorbital infection of male CD-1 mice other model (retroorbital infection of male CD-1 mice) A. fumigatus Afu6g04740 ORF act1 ASPL0000108928 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g04820 ORF pabA ASPL0000108936 PMID: 10931287|AspGD_REF: ASPL0000111272 classical genetics unspecified auxotrophy 4-aminobenzoic acid Signature-tagged mutagenesis (STM) mutant A. fumigatus Afu6g04820 ORF pabA ASPL0000108936 PMID: 10931287|AspGD_REF: ASPL0000111272 classical genetics unspecified virulence: decreased 24 to 30 g CD1 outbred male mice Signature-tagged mutagenesis (STM) strain immunosuppressed mouse pulmonary infection (hydrocortisone and cyclophospamide immunosuppression) A. fumigatus Afu6g04820 ORF pabA ASPL0000108936 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu6g04820 ORF pabA ASPL0000108936 PMID: 20950221|AspGD_REF: ASPL0000112697 classical genetics null virulence: decreased insect infection (Galleria mellonella) A. fumigatus Afu6g04910 ORF ASPL0000108945 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g05040 ORF ASPL0000108958 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g06810 ORF ASPL0000109043 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g06890 ORF ASPL0000109051 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g07120 ORF nudC ASPL0000109074 PMID: 14516763|AspGD_REF: ASPL0000079912 classical genetics repressible alcA(p)-nudC (A. nidulans alcA promoter) inviable A. fumigatus Afu6g07210 ORF sod4 ASPL0000109083 PMID: 20487287|AspGD_REF: ASPL0000111078 classical genetics null inviable no sod4::HPH deletion mutant were obtained by conidial electroporation despite several attempts and was confirmed by the heterokaryon rescue technique A. fumigatus Afu6g07390 ORF lysB ASPL0000109101 PMID: 15365692|AspGD_REF: ASPL0000111197 classical genetics null lysB::pyrG viable A. fumigatus Afu6g07390 ORF lysB ASPL0000109101 PMID: 15365692|AspGD_REF: ASPL0000111197 classical genetics null lysB::pyrG auxotrophy lysine A. fumigatus Afu6g08330 ORF ASPL0000109190 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null acyA::hph viable A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null acyA::hph colony size: decreased colony size partially restored by exogenous cAMP A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null acyA::hph conidiation: absent A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 12734751|AspGD_REF: ASPL0000111265 classical genetics null acyA::hph resistance to killing by host cells: decreased intracellular conidial killing assay with human monocyte derived macrophages A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null RNA accumulation: decreased exogenous cAMP restores wild-type dprA expression dprA mRNA A. fumigatus Afu6g08520 ORF acyA ASPL0000109208 PMID: 15322014|AspGD_REF: ASPL0000111343 classical genetics null protein activity: decreased cAMP-dependent protein kinase A. fumigatus Afu6g09070 ORF ASPL0000109262 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g09630 ORF gliZ ASPL0000109319 PMID: 17030582|AspGD_REF: ASPL0000111128 classical genetics null gliZ::pyrG viable A. fumigatus Afu6g09630 ORF gliZ ASPL0000109319 PMID: 17030582|AspGD_REF: ASPL0000111128 classical genetics null gliZ::pyrG secondary metabolite production: absent gliotoxin A. fumigatus Afu6g09630 ORF gliZ ASPL0000109319 PMID: 17030582|AspGD_REF: ASPL0000111128 classical genetics null gliZ::pyrG virulence: normal gliotoxin A. fumigatus Afu6g09630 ORF gliZ ASPL0000109319 PMID: 17030582|AspGD_REF: ASPL0000111128 classical genetics overexpression secondary metabolite production: increased gliotoxin A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 16956378|AspGD_REF: ASPL0000111334 classical genetics null gliP::phl viable A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 16956378|AspGD_REF: ASPL0000111334 classical genetics null gliP::phl virulence: normal immunosuppressed mouse pulmonary infection (low-dose model; cyclophosphamide and cortisone acetate immunosupression) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 16757745|AspGD_REF: ASPL0000079985 classical genetics null gliP::pyrG viable A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 16757745|AspGD_REF: ASPL0000079985 classical genetics null gliP::pyrG virulence: normal immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 16757745|AspGD_REF: ASPL0000079985 classical genetics null chemical compound accumulation: decreased gliotoxin A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 17601876|AspGD_REF: ASPL0000111255 classical genetics null virulence: decreased 10 to 11 week old male BALB/c mice immunosuppressed mouse pulmonary infection (hydrocortisone acetate immunosuppression) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 17601876|AspGD_REF: ASPL0000111255 classical genetics null virulence: decreased 10 to 11 week old male 129/Sv mice immunosuppressed mouse pulmonary infection (hydrocortisone acetate immunosuppression) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 18199036|AspGD_REF: ASPL0000111321 classical genetics null gliP::hph chemical compound accumulation: absent gliotoxin A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 18199036|AspGD_REF: ASPL0000111321 classical genetics null gliP::hph viable A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 18199036|AspGD_REF: ASPL0000111321 classical genetics null gliP::hph virulence: normal gliotoxin immunosuppressed mouse pulmonary infection (neutropenic mice) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 18199036|AspGD_REF: ASPL0000111321 classical genetics null gliP::hph virulence: decreased gliotoxin immunosuppressed mouse pulmonary infection (non-neutropenic mice) A. fumigatus Afu6g09660 ORF gliP ASPL0000109322 PMID: 18199036|AspGD_REF: ASPL0000111321 classical genetics null gliP::hph virulence: decreased gliotoxin insect infection (Toll-deficient D. melanogaster) A. fumigatus Afu6g09670 ORF gliC ASPL0000109323 PMID: 21749092|AspGD_REF: ASPL0000166435 classical genetics null chemical compound accumulation: absent gliotoxin A. fumigatus Afu6g09670 ORF gliC ASPL0000109323 PMID: 21749092|AspGD_REF: ASPL0000166435 classical genetics null viable A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21749092|AspGD_REF: ASPL0000166435 classical genetics null chemical compound accumulation: absent gliotoxin mutants have complete abrogation of gliotoxin biosynthesis A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21513890|AspGD_REF: ASPL0000166048 classical genetics null gliG::ptrA viable A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21513890|AspGD_REF: ASPL0000166048 classical genetics null gliG::ptrA chemical compound accumulation: absent gliotoxin A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21513890|AspGD_REF: ASPL0000166048 classical genetics null gliG::ptrA resistance to chemicals: normal gliotoxin A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21513890|AspGD_REF: ASPL0000166048 classical genetics null gliG::ptrA induction of host response: abnormal mutants induce greater melanization in the Galleria mellonella virulence model although no statistical significance was observed insect infection (Galleria mellonella virulence model) A. fumigatus Afu6g09690 ORF gliG ASPL0000109325 PMID: 21513890|AspGD_REF: ASPL0000166048 classical genetics null gliG::ptrA chemical compound accumulation: increased 6-benzyl-6-hydroxy-1-methoxy-3-methylenepiperazine-2,5-dione A. fumigatus Afu6g09740 ORF gliT ASPL0000109330 PMID: 20548963|AspGD_REF: ASPL0000101182 classical genetics null resistance to chemicals: decreased exogenous gliotoxin A. fumigatus Afu6g09740 ORF gliT ASPL0000109330 PMID: 20548963|AspGD_REF: ASPL0000101182 classical genetics null chemical compound excretion: decreased gliotoxin A. fumigatus Afu6g09740 ORF gliT ASPL0000109330 PMID: 20548963|AspGD_REF: ASPL0000101182 classical genetics null viable A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18608886|AspGD_REF: ASPL0000111140 classical genetics null yap1::pyrG viable A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18608886|AspGD_REF: ASPL0000111140 classical genetics null yap1::pyrG oxidative stress resistance: decreased hydrogen peroxide (2 to 5 mM) A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18608886|AspGD_REF: ASPL0000111140 classical genetics null yap1::pyrG oxidative stress resistance: decreased menadione (5 to 30 mM) A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18608886|AspGD_REF: ASPL0000111140 classical genetics null yap1::pyrG virulence: normal immunosuppressed mouse pulmonary infection (cyclophosphamide and triamcinolone acetonide immunosuppression) A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 20376564|AspGD_REF: ASPL0000111239 classical genetics activation yap1-TR (truncated version of yap1 lacking the CRD region) resistance to chemicals: increased voriconazole A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 20376564|AspGD_REF: ASPL0000111239 classical genetics activation yap1-TR (truncated version of yap1 lacking the CRD region) oxidative stress resistance: increased hydrogen peroxide A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 20376564|AspGD_REF: ASPL0000111239 classical genetics activation yap1-TR (truncated version of yap1 lacking the CRD region) oxidative stress resistance: increased menadione A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 20376564|AspGD_REF: ASPL0000111239 classical genetics activation yap1-TR (truncated version of yap1 lacking the CRD region) oxidative stress resistance: increased diamide A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide AspF3 A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide 2D-PAGE Prx1 A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide 2D-PAGE Ccp1 A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide 2D-PAGE Cat2 A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide 2D-PAGE TktA A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 18651311|AspGD_REF: ASPL0000111314 classical genetics null protein/peptide accumulation: decreased after challenge with 2mM hydrogen peroxide 2D-PAGE Hsp70 A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 17921349|AspGD_REF: ASPL0000111324 classical genetics null yap1::hygB viable A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 17921349|AspGD_REF: ASPL0000111324 classical genetics null yap1::hygB resistance to chemicals: decreased hydrogen peroxide A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 17921349|AspGD_REF: ASPL0000111324 classical genetics null yap1::hygB resistance to chemicals: decreased menadione A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 17921349|AspGD_REF: ASPL0000111324 classical genetics null yap1::hygB virulence: normal immunosuppressed mouse pulmonary infection (low-dose model; cyclophosphamide and cortisone acetate immunosuppressed) A. fumigatus Afu6g09930 ORF yap1 ASPL0000109349 PMID: 17921349|AspGD_REF: ASPL0000111324 classical genetics null yap1::hygB resistance to killing by host cells: normal freshly isolated human PMN A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph conidiation: delayed liquid YG medium, 48 hrs mutants produce about a third the conidiophores of wild-type in liquid culture, conidiation on plates is normal A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph resistance to enzymatic treatment: increased novozym 234 A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph viable A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph resistance to chemicals: increased vinclozolin A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph resistance to chemicals: increased vinclozolin (a dicarboximide) A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph resistance to chemicals: increased iprodione (a dicarboximide) A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 11118135|AspGD_REF: ASPL0000111270 classical genetics null fos-1::hph resistance to chemicals: increased procymidone (a dicarboximide) A. fumigatus Afu6g10240 ORF fos-1 ASPL0000109380 PMID: 12146755|AspGD_REF: ASPL0000111391 classical genetics null fos-1::hph virulence: decreased 8 x 10^6 conidia decreased fungal burden in brain and kidneys mouse intravenous infection (6 week old female CD-1 mice) A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph RNA accumulation: increased brlA mRNA A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph viable A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph cell wall morphology: abnormal A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph RNA accumulation: increased abaA mRNA A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph RNA accumulation: increased stuA mRNA A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph RNA accumulation: increased rodA mRNA A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null gel2::hph virulence: decreased 16 to 18 g female Swiss mice wild-type and mutant mixed infection (fungal burden determined by quantitation of wild-type and mutant DNA in the lungs using quantitative real-time PCR) immunosuppressed mouse pulmonary infection (cortisone acetate immunosuppression) A. fumigatus Afu6g11390 ORF gel2 ASPL0000109488 PMID: 15916615|AspGD_REF: ASPL0000111211 classical genetics null formation of anatomical structure: abnormal Sabouraud liquid medium, 24 h conidiophores are either short or appear as hyphae growing out of vesicles conidiophore A. fumigatus Afu6g12180 ORF dprB ASPL0000109563 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null colony appearance: abnormal abnormal colony morphology when grown in the presence of sorbitol A. fumigatus Afu6g12180 ORF dprB ASPL0000109563 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null viable A. fumigatus Afu6g12180 ORF dprB ASPL0000109563 PMID: 21490150|AspGD_REF: ASPL0000165821 classical genetics null utilization of carbon source: decreased growth impaired when short-chain fatty acids (butyrate (C4), valerate (C5), hexanoate (C6)) are used as sole carbon sources, but not with longer-chain fatty acids A. fumigatus Afu6g12390 ORF lcbA ASPL0000109583 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g12400 ORF fks1 ASPL0000109584 PMID: 15321679|AspGD_REF: ASPL0000111344 classical genetics reduction of function fks1-RNAi colony size: decreased A. fumigatus Afu6g12400 ORF fks1 ASPL0000109584 PMID: 17724146|AspGD_REF: ASPL0000111119 classical genetics gain of function fks1(S678P) resistance to chemicals: increased echinocandin A. fumigatus Afu6g12400 ORF fks1 ASPL0000109584 PMID: 12136012|AspGD_REF: ASPL0000114912 classical genetics null inviable haploidization of diploids assay using parasexual genetics A. fumigatus Afu6g12400 ORF fks1 ASPL0000109584 PMID: 12136012|AspGD_REF: ASPL0000114912 classical genetics reduction of function fks1::hph-pyrG/fks1+ colony size: decreased A. fumigatus Afu6g12520 ORF skn7 ASPL0000109595 PMID: 17337219|AspGD_REF: ASPL0000111150 classical genetics null viable A. fumigatus Afu6g12520 ORF skn7 ASPL0000109595 PMID: 17337219|AspGD_REF: ASPL0000111150 classical genetics null oxidative stress resistance: decreased hydrogen peroxide A. fumigatus Afu6g12520 ORF skn7 ASPL0000109595 PMID: 17337219|AspGD_REF: ASPL0000111150 classical genetics null oxidative stress resistance: decreased tert-butyl hydroperoxide A. fumigatus Afu6g12520 ORF skn7 ASPL0000109595 PMID: 17337219|AspGD_REF: ASPL0000111150 classical genetics null resistance to killing by host cells: normal alveolar macrophages obtained from animals at 24 h post-infection killing of mutant conidia similar to wild-type A. fumigatus Afu6g12520 ORF skn7 ASPL0000109595 PMID: 17337219|AspGD_REF: ASPL0000111150 classical genetics null virulence: normal immunosuppressed mouse pulmonary infection A. fumigatus Afu6g12630 ORF ASPL0000109606 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g12830 ORF ASPL0000109626 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g13300 ORF ASPL0000109671 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g13410 ORF ASPL0000109682 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g14040 ORF och2 ASPL0000109743 PMID: 20586114|AspGD_REF: ASPL0000111234 classical genetics null och2::BLE viable A. fumigatus Afu6g14090 ORF ASPL0000109748 PMID: 17557878|AspGD_REF: ASPL0000111285 classical genetics null viable A. fumigatus Afu6g14190 ORF ASPL0000109758 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG viable A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: decreased sodium dodecyl sulfate (0.1%) A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: increased calcium dichloride (500 mM) A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: decreased voriconazole A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: decreased itraconazole A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: decreased amphotericin B A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG RNA accumulation: decreased decreased levels in mutant following exposure to calcium chloride pmcA mRNA A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG RNA accumulation: decreased decreased levels in mutant following exposure to calcium chloride pmcB mRNA A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG resistance to chemicals: decreased EGTA A. fumigatus Afu6g14240 ORF ncsA ASPL0000109763 PMID: 18830711|AspGD_REF: ASPL0000111116 classical genetics null ncsA::pyrG virulence: normal immunosuppressed mouse pulmonary infection (low-dose model) A. fumigatus Afu7g00510 ORF ASPL0000109849 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu7g01790 ORF ssu1 ASPL0000109974 PMID: 17322211|AspGD_REF: ASPL0000111124 classical genetics null ssu1::hph resistance to chemicals: decreased sulfite A. fumigatus Afu7g01790 ORF ssu1 ASPL0000109974 PMID: 17322211|AspGD_REF: ASPL0000111124 classical genetics null ssu1::hph viable A. fumigatus Afu7g03740 ORF cyp51B ASPL0000110069 PMID: 15855543|AspGD_REF: ASPL0000111209 classical genetics null viable A. fumigatus Afu7g04390 ORF ASPL0000110133 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu7g04670 ORF ASPL0000110160 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu7g04800 ORF gprC ASPL0000110173 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprC::pyrG viable A. fumigatus Afu7g04800 ORF gprC ASPL0000110173 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprC::pyrG colony size: decreased phenotype prominant at high temperature (48 degrees C) A. fumigatus Afu7g04800 ORF gprC ASPL0000110173 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprC::pyrG conidial germination: delayed A. fumigatus Afu7g04800 ORF gprC ASPL0000110173 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprC::pyrG resistance to chemicals: decreased hydrogen peroxide 10% larger inhibition zone than wild-type A. fumigatus Afu7g04800 ORF gprC ASPL0000110173 PMID: 20418440|AspGD_REF: ASPL0000111081 classical genetics null gprC::pyrG virulence: decreased immunosuppressed mouse pulmonary infection (cyclophosphamide and cortisone acetate immunosuppression; low-dose model) A. fumigatus Afu7g05340 ORF ASPL0000110227 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu7g05910 ORF uapC ASPL0000110283 PMID: 17881254|AspGD_REF: ASPL0000081382 classical genetics null resistance to chemicals: increased oxypurinol A. fumigatus Afu7g05910 ORF uapC ASPL0000110283 PMID: 17881254|AspGD_REF: ASPL0000081382 classical genetics null viable A. fumigatus Afu8g00170 ORF ftmA ASPL0000110458 PMID: 16755625|AspGD_REF: ASPL0000081406 classical genetics overexpression chemical compound accumulation: increased brevianamide F A. fumigatus Afu8g00170 ORF ftmA ASPL0000110458 PMID: 16755625|AspGD_REF: ASPL0000081406 classical genetics null viable: increased A. fumigatus Afu8g00230 ORF ftmF ASPL0000110464 PMID: 21404415|AspGD_REF: ASPL0000166032 classical genetics null secondary metabolite production: decreased A. fumigatus Afu8g00230 ORF ftmF ASPL0000110464 PMID: 21404415|AspGD_REF: ASPL0000166032 classical genetics null viable A. fumigatus Afu8g00540 ORF nrps14 ASPL0000110494 PMID: 17722120|AspGD_REF: ASPL0000111120 classical genetics null viable A. fumigatus Afu8g00540 ORF nrps14 ASPL0000110494 PMID: 17722120|AspGD_REF: ASPL0000111120 classical genetics null chemical compound accumulation: decreased pseurotin A A. fumigatus Afu8g00540 ORF nrps14 ASPL0000110494 PMID: 17722120|AspGD_REF: ASPL0000111120 classical genetics overexpression chemical compound accumulation: increased pseurotin A A. fumigatus Afu8g01050 ORF afl1-1 ASPL0000110544 PMID: 21744116|AspGD_REF: ASPL0000166452 classical genetics unspecified afl1-1(H283A) and (D264A) (site directed mutants) protein activity: increased lipase A. fumigatus Afu8g01050 ORF afl1-1 ASPL0000110544 PMID: 21744116|AspGD_REF: ASPL0000166452 classical genetics unspecified afl1-1(S165A) and (H290A) (site directed mutants) protein activity: decreased lipase A. fumigatus Afu8g01230 ORF tmpL ASPL0000110562 PMID: 19893627|AspGD_REF: ASPL0000111242 classical genetics null mitochondrial morphology: abnormal mitochondria were less well defined ,often displayed discontinuous or missing outer membranes A. fumigatus Afu8g01230 ORF tmpL ASPL0000110562 PMID: 19893627|AspGD_REF: ASPL0000111242 classical genetics null virulence: decreased outbred CD1 mice immunosuppressed mouse pulmonary infection (cyclophosphamide and Kenalog immunosuppression) A. fumigatus Afu8g01230 ORF tmpL ASPL0000110562 PMID: 19893627|AspGD_REF: ASPL0000111242 classical genetics null resistance to chemicals: decreased hydrogen peroxide mutant germlings were more sensitive to H2O2 than the wild-type A. fumigatus Afu8g01670 ORF cat2 ASPL0000110606 PMID: 20145078|AspGD_REF: ASPL0000111297 classical genetics null virulence: decreased 18-20g female nude BALB/c mice skin lesion areas correlate with tissue fungal burdens other model (cutaneous invasive aspergillosis; subcutaneous injection of conidia) A. fumigatus Afu8g02040 ORF och3 ASPL0000110642 PMID: 20586114|AspGD_REF: ASPL0000111234 classical genetics null och3::pyrG (A. niger pyrG) viable A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo viable A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo colony size: decreased A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo conidiation: decreased A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo thermotolerance: decreased above 48 degrees C A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo resistance to chemicals: decreased hygromycin A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo virulence: decreased immunosuppressed mouse pulmonary infection (glucocorticoid triamcinolone acetonide and cyclophosphamide immunosuppression) A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 15271935|AspGD_REF: ASPL0000111264 classical genetics null cgrA::phleo virulence: decreased insect infection (spz mutant flies) A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 18296619|AspGD_REF: ASPL0000111428 classical genetics null cgrA::phleo viable A. fumigatus Afu8g02750 ORF cgrA ASPL0000110711 PMID: 18296619|AspGD_REF: ASPL0000111428 classical genetics null cgrA::phleo protein/peptide accumulation: decreased ribosome A. fumigatus Afu8g04420 ORF ASPL0000110777 PMID: 20097738|AspGD_REF: ASPL0000112928 classical genetics unspecified inviable Inability of haploid strains to grow on medium without uridine and uracil supplementation deemed to be due to the insertion of imp160::pyrG at a locus critical for growth or spore formation A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 chemical compound accumulation: increased chitin chitin was increased by 78% in the repressed mutant strain A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased ags1 mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased repressed ags1 mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased repressed ags3 mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased repressed gel1 mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased repressed gel2 mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 RNA accumulation: increased repressed fskA mRNA A. fumigatus Afu8g04430 ORF ASPL0000110778 PMID: 21527474|AspGD_REF: ASPL0000166047 classical genetics repressible PniiA-STT3 resistance to chemicals: decreased Calcofluor White|Congo Red only a slight increase in sensitivity A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph conidiation: decreased conidiation reduced by 90% compared to wild-type level A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph protein/peptide modification: abnormal Gel1p A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph protein/peptide modification: abnormal ChiA1p A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph colony size: decreased 48 h growth on 3% glucose, 1% YE medium, 37 degrees C Four times smaller than wild-type colonies; colony size restored with osmotic stabilizer A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph conidial germination: delayed 2 h delay in germination; wild-type levels reached after 9 hr incubation A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null resistance to chemicals: decreased echinochandins beta(1-3)glucan synthase inhibitors, caspofungin, micafungin or anidulafungin immunosuppressed mouse pulmonary infection (cyclophosphamide immunosuppression) A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph virulence: normal 8 to 12 week old white SPF CD1 (ICR) male mice, 22 to 24 g immunosuppressed mouse pulmonary infection (cyclophosphamide immunosuppression) A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph viable A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph heat sensitivity: increased growth of mutant completely abolished at 50 degrees C A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph hyphal growth: abnormal wide hyphae with short intercalary cells; hyphal ballooning seen after 48?h of culture A. fumigatus Afu8g04500 ORF pmt4 ASPL0000110785 PMID: 20398215|AspGD_REF: ASPL0000111082 classical genetics null pmt4::hph protein secretion: increased double the amount of proteins found in the culture filtrate of the pmt4 mutant than in wild-type A. fumigatus Afu8g05010 ORF zfpA ASPL0000110834 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased itraconazole A. fumigatus Afu8g05010 ORF zfpA ASPL0000110834 PMID: 19573616|AspGD_REF: ASPL0000111377 classical genetics null resistance to chemicals: increased caspofungin A. fumigatus Afu8g06550 ORF cafB ASPL0000110984 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafB::pyrG viable A. fumigatus Afu8g06550 ORF cafB ASPL0000110984 PMID: 20149101|AspGD_REF: ASPL0000089759 classical genetics null cafB::pyrG virulence: normal immunosuppressed mouse pulmonary infection (low-dose model) A. fumigatus MAT1-1 not in systematic sequence MAT1-1 ASPL0000111221 PMID: 20818921|AspGD_REF: ASPL0000111474 classical genetics null virulence: decreased insect infection (G. mellonella larvae) A. fumigatus